Shared genetic architectures of subjective well-being in East Asian and European ancestry populations
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Soyeon | - |
dc.contributor.author | Kim, Kiwon | - |
dc.contributor.author | Hwang, Mi Yeong | - |
dc.contributor.author | Ko, Hyunwoong | - |
dc.contributor.author | Jung, Sang-Hyuk | - |
dc.contributor.author | Shim, Injeong | - |
dc.contributor.author | Cha, Soojin | - |
dc.contributor.author | Lee, Hyewon | - |
dc.contributor.author | Kim, Beomsu | - |
dc.contributor.author | Yoon, Joohyun | - |
dc.contributor.author | Ha, Tae Hyon | - |
dc.contributor.author | Kim, Doh Kwan | - |
dc.contributor.author | Kim, Jinho | - |
dc.contributor.author | Park, Woong-Yang | - |
dc.contributor.author | Okbay, Aysu | - |
dc.contributor.author | Kim, Bong-Jo | - |
dc.contributor.author | Kim, Young Jin | - |
dc.contributor.author | Myung, Woojae | - |
dc.contributor.author | Won, Hong-Hee | - |
dc.date.accessioned | 2022-08-01T01:40:32Z | - |
dc.date.available | 2022-08-01T01:40:32Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 2397-3374 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21269 | - |
dc.description.abstract | Subjective well-being (SWB) has been explored in European ancestral populations; however, whether the SWB genetic architecture is shared across populations remains unclear. We conducted a cross-population genome-wide association study for SWB using samples from Korean (n = 110,919) and European (n = 563,176) ancestries. Five ancestry-specific loci and twelve cross-ancestry significant genomic loci were identified. One novel locus (rs12298541 near HMGA2) associated with SWB was also identified through the European meta-analysis. Significant cross-ancestry genetic correlation for SWB between samples was observed. Polygenic risk analysis in an independent Korean cohort (n = 22,455) demonstrated transferability between populations. Significant correlations between SWB and major depressive disorder, and significant enrichment of central nervous system-related polymorphisms heritability in both ancestry populations were found. Hence, large-scale cross-ancestry genome-wide association studies can advance our understanding of SWB genetic architecture and mental health. Won et al. compare genetic associations with subjective well-being in Korean and European populations, and show significant cross-population genetic correlations | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Shared genetic architectures of subjective well-being in East Asian and European ancestry populations | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1038/s41562-022-01343-5 | - |
dc.identifier.scopusid | 2-s2.0-85130218941 | - |
dc.identifier.wosid | 000798208300005 | - |
dc.identifier.bibliographicCitation | Nature Human Behaviour, v.6, no.7, pp 1014 - 1026 | - |
dc.citation.title | Nature Human Behaviour | - |
dc.citation.volume | 6 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1014 | - |
dc.citation.endPage | 1026 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Psychology | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Psychology, Biological | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Psychology, Experimental | - |
dc.subject.keywordPlus | CELL SELF-RENEWAL | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | RESOURCE | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | CORTEX | - |
dc.subject.keywordPlus | LOCI | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | BIAS | - |
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