Development of GO/Co/Chitosan-Based Nano-Biosensor for Real-Time Detection of D-Glucoseopen access
- Authors
- Kim, Dong Sup; Yang, Xiaoguang; Lee, Ja Hyun; Yoo, Hah Young; Park, Chulhwan; Kim, Seung Wook; Lee, Jinyoung
- Issue Date
- Jul-2022
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- GO/Co/chitosan; nano-biosensor; real-time detection; D-glucose; glucose oxidase
- Citation
- Biosensors, v.12, no.7, pp 1 - 12
- Pages
- 12
- Journal Title
- Biosensors
- Volume
- 12
- Number
- 7
- Start Page
- 1
- End Page
- 12
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21295
- DOI
- 10.3390/bios12070464
- ISSN
- 2079-6374
- Abstract
- Electrochemical nano-biosensor systems are popular in the industrial field, along with evaluations of medical, agricultural, environmental and sports analysis, because they can simultaneously perform qualitative and quantitative analyses with high sensitivity. However, real-time detection using an electrochemical nano-biosensor is greatly affected by the surrounding environment with the performance of the electron transport materials. Therefore, many researchers are trying to find good factors for real-time detection. In this work, it was found that a composite composed of graphite oxide/cobalt/chitosan had strong stability and electron transfer capability and was applied to a bio-electrochemical nano-biosensor with high sensitivity and stability. As a mediator-modified electrode, the GO/Co/chitosan composite was electrically deposited onto an Au film electrode by covalent boding, while glucose oxidase as a receptor was immobilized on the end of the GO/Co/chitosan composite. It was confirmed that the electron transfer ability of the GO/Co/chitosan composite was excellent, as shown with power density analysis. In addition, the real-time detection of D-glucose could be successfully performed by the developed nano-biosensor with a high range of detected concentrations from 1.0 to 15.0 mM. Furthermore, the slope value composed of the current, per the concentration of D-glucose as a detection response, was significantly maintained even after 14 days.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21295)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.