Granulocyte colony-stimulating factor in bronchoalveolar lavage fluid is a potential biomarker for prognostic prediction of idiopathic pulmonary fibrosis
DC Field | Value | Language |
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dc.contributor.author | Lee, Jong-Uk | - |
dc.contributor.author | Choi, Jae Sung | - |
dc.contributor.author | Kim, Min Kyung | - |
dc.contributor.author | Min, Sun A. | - |
dc.contributor.author | Park, Jong-Sook | - |
dc.contributor.author | 박춘식 | - |
dc.date.accessioned | 2022-10-05T01:41:06Z | - |
dc.date.available | 2022-10-05T01:41:06Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.issn | 2005-6648 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21457 | - |
dc.description.abstract | Background/Aims: Neutrophilia is frequently observed in bronchoalveolar lavage fluid (BALE) of idiopathic pulmonary fibrosis (IPF) patients. Granulocyte colony-stimulating factor (G-CSF) is a potent neutrophil-activating glycoprotein. However, the clinical implications of G-CSF remain poorly understood.in patients with IPF. Therefore, we evaluated the relationship between the G-CSF concentration in BALF and the progression of fibrosis, including in terms of the decline in lung function and long-term survival rate. Methods: G-CSF concentrations were measured in BALF using enzyme-linked immunosorbent assay (ELISA). The survival rate was estimated using Kaplan-Meier survival analyses. Results: G-CSF protein levels were significantly higher in IPF (n = 87; 1.88 [0 to 5.68 pg/mL]), nonspecific interstitial pneumonia (n = 22; 0.58 [0 to 11.64 pg/mL]), and hypersensitivity pneumonitis (n = 19; 2.48 [0.46 to 5.71 pg/mL]) patients than in normal controls (n = 33; 0 [0 to 0.68 pg/mL]) (all p < 0.01). A receiver operating characteristic curve showed a difference in G-CSF levels between IPF and NC (area under the curve, 0.769): The G-CSF cut-off of 0.96 pg/mL indicated 84.9% specificity and 63.2% sensitivity for IPF. The survival rate was significantly lower in the group with G-CSF > 2.872 pg/mL than in the group with <= 2.872 pg/mL (hazard ratio, 2.69; p = 0.041). The annual decline in diffusing capacity of the lung for carbon monoxide was positively correlated with the G-CSF level (p = 0.018). Conclusions: G-CSF may participate in the development of IPF and be useful for predicting the prognosis of IPF. Therefore, G-CSF should be analyzed in BALF, in addition to differential cell counts. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한내과학회 | - |
dc.title | Granulocyte colony-stimulating factor in bronchoalveolar lavage fluid is a potential biomarker for prognostic prediction of idiopathic pulmonary fibrosis | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3904/kjim.2021.442 | - |
dc.identifier.scopusid | 2-s2.0-85137745740 | - |
dc.identifier.wosid | 000827229100001 | - |
dc.identifier.bibliographicCitation | The Korean Journal of Internal Medicine, v.37, no.5, pp 979 - 988 | - |
dc.citation.title | The Korean Journal of Internal Medicine | - |
dc.citation.volume | 37 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 979 | - |
dc.citation.endPage | 988 | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | INTERSTITIAL PNEUMONIA | - |
dc.subject.keywordPlus | NEUTROPHIL | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Granulocyte colony-stimulating factor | - |
dc.subject.keywordAuthor | Neutrophils | - |
dc.subject.keywordAuthor | Idiopathic pulmonary fibrosis | - |
dc.subject.keywordAuthor | Survival | - |
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