Value of C-11 methionine PET/CT in patients with intracranial germinoma
DC Field | Value | Language |
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dc.contributor.author | Park, Yong-Jin | - |
dc.contributor.author | Lee, Ji Won | - |
dc.contributor.author | Cho, Hee Won | - |
dc.contributor.author | Choe, Yearn Seong | - |
dc.contributor.author | Lee, Kyung-Han | - |
dc.contributor.author | Choi, Joon Young | - |
dc.contributor.author | Sung, Ki Woong | - |
dc.contributor.author | Moon, Seung Hwan | - |
dc.date.accessioned | 2022-11-29T02:41:09Z | - |
dc.date.available | 2022-11-29T02:41:09Z | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21713 | - |
dc.description.abstract | Purpose The purpose of this study was to investigate the value of C-11 methionine (MET) positron emission tomography (PET)/computed tomography (CT) in patients with intracranial germinoma (IG). Material and methods We conducted a retrospective analysis of 21 consecutive patients with pathologically confirmed IGs and eight patients with intracranial non-germinomas (INGs) located in a similar region. Clinical characteristics, imaging findings, and tumor markers such as alpha-fetoprotein (AFP) and beta-human chorionic gonadotropin (HCG) were used as clinical variables. Maximum standardized uptake value (SUVmax), tumor-to-normal tissue (T/N) ratio, and visual scoring of tumor were used as MET PET parameters. Results All IGs were well visualized on MET PET with a three-grade visual scoring system. In addition, SUVmax of IGs was higher than that of INGs (P = 0.005). Pre-treatment (Pre-Tx) T/N ratio was significantly correlated with pre-Tx serum HCG (P = 0.031). Moreover, MET PET parameters showed significant associations with tumor location, sex, KRAS variant, and symptoms. Conclusion MET PET/CT could be a useful diagnostic tool in patients suspected of having IGs. In addition, the MET avidity of tumor is a potential surrogate biomarker of HCG, which has been used as a diagnostic marker for IGs. Tumor MET parameters also had significant differences according to tumor locations, sex, symptoms, and KRAS mutation. However, MET avidity of tumors had no significant prognostic value. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Public Library of Science | - |
dc.title | Value of C-11 methionine PET/CT in patients with intracranial germinoma | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1371/journal.pone.0263690 | - |
dc.identifier.scopusid | 2-s2.0-85124238260 | - |
dc.identifier.wosid | 000805530700045 | - |
dc.identifier.bibliographicCitation | PLoS ONE, v.17, no.2 | - |
dc.citation.title | PLoS ONE | - |
dc.citation.volume | 17 | - |
dc.citation.number | 2 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | BASAL GANGLIA GERMINOMA | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | C-11-METHIONINE | - |
dc.subject.keywordPlus | BIOPSY | - |
dc.subject.keywordPlus | TUMOR | - |
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