Long-Term Outcomes of Bilateral Subthalamic Nucleus Deep Brain Stimulation for Patients With Parkinson's Disease: 10 Years and Beyond
DC Field | Value | Language |
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dc.contributor.author | Park, Hye Ran | - |
dc.contributor.author | Im, Hyung-Jun | - |
dc.contributor.author | Park, Jeongbin | - |
dc.contributor.author | Yoon, Byung Woo | - |
dc.contributor.author | Lim, Yong Hoon | - |
dc.contributor.author | Song, Eun Jin | - |
dc.contributor.author | Kim, Kyung Ran | - |
dc.contributor.author | Lee, Jae Meen | - |
dc.contributor.author | Park, Kawngwoo | - |
dc.contributor.author | Park, Kwang Hyon | - |
dc.contributor.author | Park, Hyun Joo | - |
dc.contributor.author | Shin, Jung-Hwan | - |
dc.contributor.author | Woo, Kyung Ah | - |
dc.contributor.author | Lee, Jee Young | - |
dc.contributor.author | Park, Suyeon | - |
dc.contributor.author | Kim, Han-Joon | - |
dc.contributor.author | Jeon, Beomseok | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.date.accessioned | 2022-11-29T05:40:44Z | - |
dc.date.available | 2022-11-29T05:40:44Z | - |
dc.date.issued | 2022-11 | - |
dc.identifier.issn | 0148-396X | - |
dc.identifier.issn | 1524-4040 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21757 | - |
dc.description.abstract | BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) represents an effective treatment for severe Parkinson's disease (PD), but little is known about the long-term benefit. OBJECTIVE: To investigate the survival rate and long-term outcome of DBS. METHODS: We investigated all 81 patients including 37 males and 44 females who underwent bilateral STN DBS from March 2005 to March 2008 at a single institution. The current survival status of the patients was investigated. Preoperative and postoperative follow-up assessments were analyzed. RESULTS: The mean age at the time of surgery was 62 (range 27-82) years, and the median clinical follow-up duration was 145 months. Thirty-five patients (43%) died during the follow-up period. The mean duration from DBS surgery to death was 110.46 40.8 (range 0-155) months. The cumulative survival rate is as follows: 98.8 +/- 1.2% (1 year), 95.1 +/- 2.4% (5 years), and 79.0 +/- 4.5% (10 years). Of the 81 patients, 33 (40%) were ambulatory up to more than 11 years. The Unified Parkinson's Disease Rating Scale (UPDRS) score was significantly improved until 5 years after surgery although it showed a tendency to increase again after 10 years. The patient group with both electrodes located within the STN showed a higher rate of survival and maintained ambulation. CONCLUSION: STN DBS is a safe and effective treatment for patients with advanced PD. This study based on the long-term follow-up of large patient populations can be used to elucidate the long-term fate of patients who underwent bilateral STN DBS for PD. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | Long-Term Outcomes of Bilateral Subthalamic Nucleus Deep Brain Stimulation for Patients With Parkinson's Disease: 10 Years and Beyond | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1227/neu.0000000000002117 | - |
dc.identifier.scopusid | 2-s2.0-85140144485 | - |
dc.identifier.wosid | 000867871400026 | - |
dc.identifier.bibliographicCitation | Neurosurgery, v.91, no.5, pp 726 - 733 | - |
dc.citation.title | Neurosurgery | - |
dc.citation.volume | 91 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 726 | - |
dc.citation.endPage | 733 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | MEDICAL THERAPY | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | ELECTRODE | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | MOTOR | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordPlus | DBS | - |
dc.subject.keywordAuthor | Parkinson's disease | - |
dc.subject.keywordAuthor | Deep brain stimulation | - |
dc.subject.keywordAuthor | Treatment outcome | - |
dc.subject.keywordAuthor | Subthalamic nucleus | - |
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