Febrile Seizures Cause Depression and Anxiogenic Behaviors in Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, Yeon Hee | - |
dc.contributor.author | Kim, Seong-Wook | - |
dc.contributor.author | Im, Hyuna | - |
dc.contributor.author | Song, Yejin | - |
dc.contributor.author | Kim, Seo Jeong | - |
dc.contributor.author | Lee, Yu Ran | - |
dc.contributor.author | Kim, Gun Woo | - |
dc.contributor.author | Hwang, Changmin | - |
dc.contributor.author | Park, Dae-Kyoon | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.date.accessioned | 2022-11-29T05:41:23Z | - |
dc.date.available | 2022-11-29T05:41:23Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21775 | - |
dc.description.abstract | Febrile seizure (FS) is a common type of seizure occurring in human during infancy and childhood. Although an epileptic seizure is associated with psychiatric disorders and comorbid diseases such as depression, anxiety, autism spectrum disorders, sleep disorders, attention deficits, cognitive impairment, and migraine, the causal relationship between FS and psychiatric disorders is poorly understood. The objective of the current study was to investigate the relationship of FS occurrence in childhood with the pathogenesis of anxiety disorder and depression using an FS rat model. We induced febrile seizures in infantile rats (11 days postnatal) using a mercury vapor lamp. At 3 weeks and 12 weeks after FS induction, we examined behaviors and recorded local field potentials (LFPs) to assess anxiety and depression disorder. Interestingly, after FS induction in infantile rats, anxiogenic behaviors and depression-like phenotypes were found in both adult and juvenile FS rats. The analysis of LFPs revealed that 4-7 Hz hippocampal theta rhythm, a neural oscillatory marker for anxiety disorder, was significantly increased in FS rats compared with their wild-type littermates. Taken together, our findings suggest that FS occurrence in infants is causally related to increased levels of anxiety-related behaviors and depression-like symptoms in juvenile and adult rodents. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Febrile Seizures Cause Depression and Anxiogenic Behaviors in Rats | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/cells11203228 | - |
dc.identifier.scopusid | 2-s2.0-85140621521 | - |
dc.identifier.wosid | 000872757400001 | - |
dc.identifier.bibliographicCitation | Cells, v.11, no.20 | - |
dc.citation.title | Cells | - |
dc.citation.volume | 11 | - |
dc.citation.number | 20 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | MEDIAL PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | ANIMAL-MODEL | - |
dc.subject.keywordPlus | DELTA ACTIVITY | - |
dc.subject.keywordPlus | EPILEPSY | - |
dc.subject.keywordPlus | ANXIETY | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | OSCILLATIONS | - |
dc.subject.keywordPlus | EXCITABILITY | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.subject.keywordAuthor | febrile seizure | - |
dc.subject.keywordAuthor | emotional phenotypes | - |
dc.subject.keywordAuthor | hippocampus | - |
dc.subject.keywordAuthor | local field potentials | - |
dc.subject.keywordAuthor | theta oscillations | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.