Stereotactic body radiotherapy using helical tomotherapy for hepatocellular carcinoma: clinical outcome and dosimetric comparison of Hi-ART vs. Radixact
DC Field | Value | Language |
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dc.contributor.author | Bae, Sun Hyun | - |
dc.contributor.author | Cho, Kwang Hwan | - |
dc.contributor.author | Jung, Jae Hong | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Kim, Sang Gyune | - |
dc.contributor.author | Yoo, Jeong-Ju | - |
dc.contributor.author | Lee, Jae Myung | - |
dc.contributor.author | Lee, Min Hee | - |
dc.contributor.author | Lim, Sung Hee | - |
dc.date.accessioned | 2022-11-29T06:41:18Z | - |
dc.date.available | 2022-11-29T06:41:18Z | - |
dc.date.issued | 2022-11 | - |
dc.identifier.issn | 2218-676X | - |
dc.identifier.issn | 2219-6803 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21859 | - |
dc.description.abstract | <bold>Background</bold>: Helical tomotherapy (HT), a unique rotational dose delivery machine, has been updated from Hi-ART to Radixact. We retrospectively evaluated the treatment outcomes of stereotactic body radiotherapy (SBRT) using HT for hepatocellular carcinoma (HCC) and compared the dosimetric details of Hi-ART and Radixact. <bold>Methods</bold>: Between April 2014 and November 2020, 28 patients with HCC were treated with SBRT using HT for a cure at Soonchunhyang University College of Medicine, Bucheon. According to the Barcelona Clinic Liver Cancer classification, 9 patients had stage 0 disease, 12 had stage A, 4 had stage B, and 3 had stage C. The tumor size ranged from 1 cm to 8 cm (median, 2 cm). The SBRT dose ranged from 40 to 60 Gy (median, 48 Gy) with 4 fractions. Twenty-three patients were treated with Hi-ART and 5 patients were treated with Radixact. To compare the dosimetric parameters between Hi-ART and Radixact, we created treatment plans with the same constraints, pitch, modulation factor, and field width for the same patient in pairs.<bold>Results</bold>: The median follow-up time from the date of SBRT administration was 24 months (range, 3-67 months). The local failure-free survival and intrahepatic failure-free survival rates were 96% and 58% at 1 year, 84% and 36% at 2 years, and 76% and 18% at 3 years, respectively. The overall survival rate was 93% at 1 year, 93% at 2 years, and 53% at 3 years, respectively. When the paired treatment plans were reviewed, the beam-on time and intermediate dose-spillage were found to be significantly reduced in Radixact than Hi-ART (P<0.001). With regard to normal organ sparing, the irradiated dose to the total liver, normal liver, heart, and kidney was significantly lower with Radixact (P<0.001).<bold>Conclusions</bold>: SBRT using HT for HCC showed favorable treatment outcomes. Radixact, the latest version, physically improved treatment efficiency by reducing treatment time and provided better organ sparing than Hi-ART. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AME Publishing Company | - |
dc.title | Stereotactic body radiotherapy using helical tomotherapy for hepatocellular carcinoma: clinical outcome and dosimetric comparison of Hi-ART vs. Radixact | - |
dc.type | Article | - |
dc.publisher.location | 중국 | - |
dc.identifier.doi | 10.21037/tcr-22-1565 | - |
dc.identifier.wosid | 000883702800001 | - |
dc.identifier.bibliographicCitation | Translational Cancer Research | - |
dc.citation.title | Translational Cancer Research | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | RADIATION-THERAPY | - |
dc.subject.keywordPlus | DYNAMIC JAW | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordPlus | TOMOEDGE | - |
dc.subject.keywordPlus | CANCERS | - |
dc.subject.keywordPlus | PHANTOM | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
dc.subject.keywordAuthor | helical tomotherapy (HT) | - |
dc.subject.keywordAuthor | Hi-ART system | - |
dc.subject.keywordAuthor | Radixact | - |
dc.subject.keywordAuthor | stereotactic body radiotherapy (SBRT) | - |
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