The association of fatty liver index and BARD score with all-cause and cause-specific mortality in patients with type 2 diabetes mellitus: a nationwide population-based study
DC Field | Value | Language |
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dc.contributor.author | Chung, Goh Eun | - |
dc.contributor.author | Jeong, Su-Min | - |
dc.contributor.author | Cho, Eun Ju | - |
dc.contributor.author | Yoon, Ji Won | - |
dc.contributor.author | Yoo, Jeong-Ju | - |
dc.contributor.author | Cho, Yuri | - |
dc.contributor.author | Lee, Kyu-na | - |
dc.contributor.author | Shin, Dong Wook | - |
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Yu, Su Jong | - |
dc.date.accessioned | 2023-03-09T02:41:22Z | - |
dc.date.available | 2023-03-09T02:41:22Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 1475-2840 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22053 | - |
dc.description.abstract | Background: Type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) commonly coexist. However, NAFLD's effect on mortality in Asian patients with type 2 diabetes awaits full elucidation. Therefore, we examined NAFLD-related all-cause and cause-specific mortality in a nationwide Asian population with type 2 diabetes. Methods: We included patients who had undergone general health checkups between 2009 and 2012 using the National Health Insurance Service database linked to death-certificate data. Hepatic steatosis was defined as a fatty liver index (FLI) > 60, and advanced hepatic fibrosis was determined using the BARD score. Findings: During the follow-up period of 8.1 years, 222,242 deaths occurred, with a mortality rate of 14.3/1000 person-years. An FLI > 60 was significantly associated with increased risks of all-cause and cause-specific mortality including cardiovascular disease (CVD)-, cancer-, and liver disease (FLI > 60: hazard ratio [HR] =1.02, 95% confidence interval [CI] 1.01-1.03 for all-cause; 1.07, 1.04-1.10 for CVD; 1.12, 1.09-1.14 for cancer; and 2.63, 2.50-2.77 for liver dis-ease). Those with an FLI > 60 and fibrosis (BARD > 2) exhibited increased risks of all-cause (HR, 95% CI 1.11, 1.10-1.12), CVD-(HR, 95% CI 1.11, 1.09-1.14), cancer-(HR, 95% CI 1.17, 1.15-1.19), and liver disease-related (HR, 95% CI 2.38, 2.29-2.49) mortality. Conclusion: Hepatic steatosis and advanced fibrosis were significantly associated with risks of overall and cause-specific mortality in patients with type 2 diabetes. Our results provide evidence that determining the presence of hepatic steatosis and/or fibrosis potentially plays a role in risk stratification of mortality outcomes in patients with type 2 diabetes mellitus. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BioMed Central | - |
dc.title | The association of fatty liver index and BARD score with all-cause and cause-specific mortality in patients with type 2 diabetes mellitus: a nationwide population-based study | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1186/s12933-022-01691-6 | - |
dc.identifier.scopusid | 2-s2.0-85143312500 | - |
dc.identifier.wosid | 000895389900001 | - |
dc.identifier.bibliographicCitation | Cardiovascular Diabetology, v.21, no.1 | - |
dc.citation.title | Cardiovascular Diabetology | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | LIPID-ACCUMULATION PRODUCT | - |
dc.subject.keywordPlus | HEPATIC STEATOSIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | OBESE | - |
dc.subject.keywordAuthor | Diabetes | - |
dc.subject.keywordAuthor | Mortality | - |
dc.subject.keywordAuthor | Cause | - |
dc.subject.keywordAuthor | Steatosis | - |
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