Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial
DC Field | Value | Language |
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dc.contributor.author | Shin, Seung Yong | - |
dc.contributor.author | Park, Sein | - |
dc.contributor.author | Moon, Jung Min | - |
dc.contributor.author | Kim, Kisung | - |
dc.contributor.author | Kim, Jeong Wook | - |
dc.contributor.author | Chun, Jongsik | - |
dc.contributor.author | Lee, Tae Hee | - |
dc.contributor.author | Choi, Chang Hwan | - |
dc.date.accessioned | 2023-03-09T02:42:38Z | - |
dc.date.available | 2023-03-09T02:42:38Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 2093-0879 | - |
dc.identifier.issn | 2093-0887 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22106 | - |
dc.description.abstract | Background/AimsWe aim to evaluate the differences in the microbiome of responders and non-responders, as well as predict the response to probiotic therapy, based on fecal microbiome data in patients with diarrhea-predominant irritable bowel syndrome (IBS-D).MethodsA multi-strain probiotics that contains Lactobacillus acidophilus (KCTC 11906BP), Lactobacillus plantarum (KCTC11867BP), Lactobacillus rhamnosus (KCTC 11868BP), Bifidobacterium breve (KCTC 11858BP), Bifidobacterium lactis (KCTC 11903BP), Bifidobacterium longum (KCTC 11860BP), and Streptococcus thermophilus (KCTC 11870BP) were used. Patients were categorized into probiotic and placebo groups, and fecal samples were collected from all patients before and at the end of 8 weeks of treatment. The probiotic group was further divided into responders and non-responders. Responders were defined as patients who experienced adequate relief of overall irritable bowel syndrome symptoms after probiotic therapy. Fecal microbiota were investigated using Illumina MiSeq and analyzed using the EzBioCloud 16S database and microbiome pipeline (https://www.EZbiocloud.net).ResultsThere was no significant difference in the alpha and beta diversity between the responder and non-responder groups. The abundances of the phylum Proteobacteria and genus Bacteroides significantly decreased after probiotic treatment. Bifidobacterium bifidum, Pediococcus acidilactici, and Enterococcus faecium showed a significantly higher abundance in the probiotic group after treatment compared to the placebo group. Enterococcus faecalis and Lactococcus lactis were identified as biomarkers of non-response to probiotics. The abundance of Fusicatenibacter saccharivorans significantly increased in the responders after treatment. ConclusionsProbiotic treatment changes some composition of fecal bacteria in patients with IBS-D. E. faecalis and L. lactis may be prediction biomarkers for non-response to probiotics. Increased abundance of F. sccharivorans is correlated to symptom improvement by probiotics in patients with IBS-D.(J Neurogastroenterol Motil 2022;28:642-654) | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한소화기 기능성질환∙운동학회 | - |
dc.title | Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5056/jnm21202 | - |
dc.identifier.scopusid | 2-s2.0-85141520665 | - |
dc.identifier.wosid | 000877926500012 | - |
dc.identifier.bibliographicCitation | Journal of Neurogastroenterology and Motility (JNM), v.28, no.4, pp 642 - 654 | - |
dc.citation.title | Journal of Neurogastroenterology and Motility (JNM) | - |
dc.citation.volume | 28 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 642 | - |
dc.citation.endPage | 654 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002893933 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | BACTEROIDES-VULGATUS | - |
dc.subject.keywordPlus | INTESTINAL MICROBIOTA | - |
dc.subject.keywordPlus | ULCERATIVE-COLITIS | - |
dc.subject.keywordPlus | FECAL MICROBIOTA | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | SYMPTOMS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | SIGNATURE | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | Biomarkers | - |
dc.subject.keywordAuthor | Irritable bowel syndrome | - |
dc.subject.keywordAuthor | Microbiota | - |
dc.subject.keywordAuthor | Prediction | - |
dc.subject.keywordAuthor | Probiotics | - |
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