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Anagliptin twice-daily regimen improves glycaemic variability in subjects with type 2 diabetes: A double-blind, randomized controlled trial

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dc.contributor.authorLee, Yong-ho-
dc.contributor.authorKim, Doo-Man-
dc.contributor.authorYu, Jae Myung-
dc.contributor.authorChoi, Kyung Mook-
dc.contributor.authorKim, Sin Gon-
dc.contributor.authorPark, Kang Seo-
dc.contributor.authorSon, Hyun-Shik-
dc.contributor.authorChung, Choon Hee-
dc.contributor.authorAhn, Kyu Jeung-
dc.contributor.authorLee, Soon Hee-
dc.contributor.authorSong, Ki-Ho-
dc.contributor.authorKwon, Su Kyoung-
dc.contributor.authorPark, Hyeong Kyu-
dc.contributor.authorWon, Kyu Chang-
dc.contributor.authorJang, Hak Chul-
dc.contributor.authorACACIA Study Grp-
dc.date.accessioned2023-04-25T02:41:07Z-
dc.date.available2023-04-25T02:41:07Z-
dc.date.issued2023-05-
dc.identifier.issn1462-8902-
dc.identifier.issn1463-1326-
dc.identifier.urihttps://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22266-
dc.description.abstractAim To determine whether the twice-daily (BID) regimen is superior to the once-daily (QD) regimen for managing glycaemic variability by comparing the effects of anagliptin 100 mg BID versus sitagliptin 100 mg QD.Materials and MethodsA double-blinded, randomized, multicentre study was performed in 89 patients with type 2 diabetes treated with metformin alone (6.5% < HbA1c < 8.5%). Subjects were randomly assigned to anagliptin 100 mg BID or sitagliptin 100 mg QD in a 1:1 ratio for 12 weeks. Continuous glucose monitoring was used to measure the mean amplitude of glycaemic excursion (MAGE) and postprandial time in range (TIR) before and after dipeptidyl peptidase-4 (DPP-4) inhibitor treatment to compare glycaemic variability.Results The decrease from baseline in MAGE at 12 weeks after DPP-4 inhibitor treatment was significantly greater in the anagliptin BID group than in the sitagliptin QD group (P < .05); -30.4 & PLUSMN; 25.6 mg/dl (P < .001) in the anagliptin group versus -9.5 & PLUSMN; 38.0 mg/dl (P = .215) in the sitagliptin group. The TIR after dinner increased by 33.0% & PLUSMN; 22.0% (P < .001) in the anagliptin group and by 14.6% & PLUSMN; 28.2% (P = .014) in the sitagliptin group, with a statistically significant difference (P = .009). No statistically significant differences were observed between the groups in the changes in HbA1c and fasting plasma glucose (FPG).Conclusions The anagliptin BID regimen for the treatment of type 2 diabetes was superior in blood glucose control after dinner to improve glycaemic variability, as indicated by MAGE and TIR, but was equivalent to the QD regimen in terms of HbA1c and FPG.-
dc.format.extent12-
dc.language영어-
dc.language.isoENG-
dc.publisherBlackwell Publishing Inc.-
dc.titleAnagliptin twice-daily regimen improves glycaemic variability in subjects with type 2 diabetes: A double-blind, randomized controlled trial-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1111/dom.14959-
dc.identifier.scopusid2-s2.0-85146192499-
dc.identifier.wosid000920673800001-
dc.identifier.bibliographicCitationDiabetes, Obesity and Metabolism, v.25, no.5, pp 1174 - 1185-
dc.citation.titleDiabetes, Obesity and Metabolism-
dc.citation.volume25-
dc.citation.number5-
dc.citation.startPage1174-
dc.citation.endPage1185-
dc.type.docTypeArticle; Early Access-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaEndocrinology & Metabolism-
dc.relation.journalWebOfScienceCategoryEndocrinology & Metabolism-
dc.subject.keywordPlusACUTE GLUCOSE FLUCTUATIONS-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusCARDIOVASCULAR-DISEASE-
dc.subject.keywordPlusRISK-FACTOR-
dc.subject.keywordPlusHYPERGLYCEMIA-
dc.subject.keywordPlusHEMOGLOBIN-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusTOLERANCE-
dc.subject.keywordPlusIMPACT-
dc.subject.keywordAuthorcontinuous glucose monitoring-
dc.subject.keywordAuthorDPP-4 inhibitor-
dc.subject.keywordAuthorglycaemic control-
dc.subject.keywordAuthorrandomized controlled trial-
dc.subject.keywordAuthortype 2 diabetes-
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