The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer A systematic review and meta-analysisopen access
- Authors
- Koh, Hyun Min; Hyun, Chang Lim; Jang, Bo Gun; Lee, Hyun Ju
- Issue Date
- 18-Dec-2020
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Keywords
- hepatoma-derived growth factor; meta-analysis; non-small cell lung cancer; prognosis
- Citation
- Medicine, v.99, no.51
- Journal Title
- Medicine
- Volume
- 99
- Number
- 51
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2230
- DOI
- 10.1097/MD.0000000000023837
- ISSN
- 0025-7974
1536-5964
- Abstract
- Background: Hepatoma-derived growth factor (HDGF) promotes cancer progression and metastasis by interacting with vascular endothelial growth factor, thereby inducing epithelial-to-mesenchymal transition and angiogenesis. Recent studies have correlated increased HDGF levels with poor prognosis in various malignancies, including lung cancer. This meta-analysis systematically assessed the prognostic significance of HDGF expression in patients with non-small cell lung cancer (NSCLC). Methods: Eligible studies were identified by searching literature in PubMed, Embase, Scopus, and the Cochrane library until June 2020. The pooled hazard ratio (HR) or odds ratio (OR) with 95% confidence interval (CI) was determined to assess the relationship between HDGF expression and clinical outcome in patients with NSCLC. Results: The pooled HRs between high HDGF expression and clinical outcome were 2.20 (95% CI 1.75-2.76, P < .001) and 2.77 (95% CI 1.79-4.29, P < .001) for overall survival and disease-free survival, respectively. High HDGF expression was significantly correlated with a larger tumor size (OR 1.59, 95% CI 1.02-2.46, P = .040). Conclusion: HDGF expression is related to clinical outcome and may be a prognostic marker in patients with NSCLC.
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Collections - College of Medicine > Department of Pathology > 1. Journal Articles
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