Time-Varying Risk Factors for Incident Fractures in Kidney Transplant Recipients: A Nationwide Cohort Study in South Korea
DC Field | Value | Language |
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dc.contributor.author | Eum, Sang Hun | - |
dc.contributor.author | Kim, Da Won | - |
dc.contributor.author | Lee, Jeong-Hoon | - |
dc.contributor.author | Jeon, Jin Seok | - |
dc.contributor.author | Jun, Heungman | - |
dc.contributor.author | Yang, Jaeseok | - |
dc.contributor.author | Kim, Myoung Soo | - |
dc.contributor.author | Yoon, Hye Eun | - |
dc.date.accessioned | 2023-04-26T02:40:20Z | - |
dc.date.available | 2023-04-26T02:40:20Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22359 | - |
dc.description.abstract | Little is known about the time-varying risk factors for fractures in kidney transplant recipients (KTRs). Using the Korea Organ Transplantation Registry, a nationwide cohort study of KTRs, the incidence, locations, and time-varying predictors of fractures were analyzed, including at baseline and post-transplant 6-month variables in KTRs who underwent KT between January 2014 and June 2019. Among 4134 KTRs, with a median follow-up of 2.94 years (12,441.04 person-years), 63 patients developed fractures. The cumulative 5-year incidence was 2.10%. The most frequent locations were leg (25.40%) and foot/ankle (22.22%). In multivariable analysis, older recipient age at baseline (hazard ratio [HR], 1.035; 95% confidence interval [CI], 1.007-1.064; p = 0.013) and higher tacrolimus trough level (HR, 1.112; 95% CI, 1.029-1.202; p = 0.029) were associated with higher risks for fractures. Pretransplant diabetes mellitus had a time-dependent impact on fractures, with increasing risk as time elapses (HR for diabetes mellitus 1.115; 95% CI, 0.439-2.832; HR for diabetes mellitus x time, 1.049; 95% CI, 1.007-1.094; p = 0.022). In conclusion, KTRs had a high risk of peripheral skeletal fractures in the first 5 years. At baseline recipient age, pretransplant diabetes mellitus and tacrolimus trough level after KT were responsible for the fractures in KTRs. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Time-Varying Risk Factors for Incident Fractures in Kidney Transplant Recipients: A Nationwide Cohort Study in South Korea | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/jcm12062337 | - |
dc.identifier.scopusid | 2-s2.0-85151731150 | - |
dc.identifier.wosid | 000958352800001 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Medicine, v.12, no.6 | - |
dc.citation.title | Journal of Clinical Medicine | - |
dc.citation.volume | 12 | - |
dc.citation.number | 6 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | EARLY CORTICOSTEROID WITHDRAWAL | - |
dc.subject.keywordPlus | BONE-MINERAL METABOLISM | - |
dc.subject.keywordPlus | RENAL-TRANSPLANTATION | - |
dc.subject.keywordPlus | CYCLOSPORINE-A | - |
dc.subject.keywordPlus | HIP | - |
dc.subject.keywordAuthor | CKD-MBD | - |
dc.subject.keywordAuthor | fracture | - |
dc.subject.keywordAuthor | kidney transplantation | - |
dc.subject.keywordAuthor | bone disease | - |
dc.subject.keywordAuthor | immunosuppression | - |
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