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The Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD): Changes in Preferred Treatment Strategies and Medications over 20 Years and Five Editionsopen access

Authors
Jang, Seung-HoBahk, Won-MyongWoo, Young SupSeo, Jeong SeokPark, Young-MinKim, WonJeong, Jong-HyunShim, Se-HoonLee, Jung GooJon, Duk-InMin, Kyung Joon
Issue Date
Feb-2023
Publisher
MDPI AG
Keywords
KAMP-DD; depressive disorder; expert consensus; treatment strategy
Citation
Journal of Clinical Medicine, v.12, no.3
Journal Title
Journal of Clinical Medicine
Volume
12
Number
3
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22365
DOI
10.3390/jcm12031146
ISSN
2077-0383
2077-0383
Abstract
Background. The Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) is an expert consensus guideline for depressive disorder created in 2002, and since then, four revisions (2006, 2012, 2017, 2021) have been published. In this study, changes in the content of the KMAP-DD survey and recommendations for each period were examined. Methods. The development process of the KMAP-DD was composed of two stages. First, opinions from experts with abundant clinical experience were gathered through surveys. Next, a final guideline was prepared through discussion within the working committee regarding the suitability of the results with reference to recent clinical studies or other guidelines. Results. In mild depressive symptoms, antidepressant (AD) monotherapy was preferred, but when severe depression or when psychotic features were present, a combination of AD and atypical antipsychotics (AD + AAP) was preferred. AD monotherapy was preferred in most clinical subtypes. AD monotherapy was preferred for mild depressive symptoms, and AD + AAP was preferred for severe depression and depression with psychotic features in children, adolescents, and the elderly. Conclusions. This study identified the changes in the KMAP-DD treatment strategies and drug preferences in each period over the past 20 years. This work is expected to aid clinicians in establishing effective treatment strategies.
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