Characteristics of Cognitive Function Changes and Related Factors in Individuals With Cognitive Impairment During the Pandemic of COVID-19: A Retrospective Chart Review Study
- Authors
- Choi, Jin-Hui; Koo, Bon-Hoon; Seo, Wan-Seok; Cheon, Eun-Jin; Sung, Hyung-Mo; Kim, Ji Yean; Jeong, Hyun-Seok; Kim, Younggyo; Kim, Hye-Geum
- Issue Date
- Feb-2023
- Publisher
- 대한신경정신의학회
- Keywords
- COVID-19; Coronavirus disease; Cognition; Dementia; Neuropsychology
- Citation
- PSYCHIATRY INVESTIGATION, v.20, no.2, pp 109 - 119
- Pages
- 11
- Journal Title
- PSYCHIATRY INVESTIGATION
- Volume
- 20
- Number
- 2
- Start Page
- 109
- End Page
- 119
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22404
- DOI
- 10.30773/pi.2022.0223
- ISSN
- 1738-3684
1976-3026
- Abstract
- Objective This study aimed to explore the characteristics and factors related to changes in cognitive function in vulnerable individuals with cognitive impairment during the coronavirus disease 2019 (COVID-19) pandemic. Methods Among patients who visited a local university hospital with subjective cognitive complaints, those who had been tested for cognitive function at least once after the onset of COVID-19 and tested regularly at least three times within the last 5 years were included (1st, the initial screening; 2nd, the test immediately before the COVID-19 pandemic; 3rd, the most recent test after the pandemic). Fi-nally, 108 patients were included in this study. They were divided into groups according to whether the Clinical Dementia Rating (CDR) was maintained/improved and deteriorated. We investigated the characteristics of the changes in cognitive function and related factors during COVID-19. Results When comparing CDR changes before and after COVID-19, there was no significant difference between the two groups (p=0.317). Alternatively, the main effect of the time when the test was conducted was significant (p<0.001). There was also a significant difference in the interaction between the groups and time. When the effect of the interaction was analyzed, the CDR score of the main-tained/improved group significantly decreased before COVID-19 (1st-2nd) (p=0.045). After COVID-19 (2nd-3rd), the CDR score of the deteriorated group was significantly higher than that of the maintained/improved group (p<0.001). Mini-Mental State Examina-tion recall memory and changes in activity during COVID-19 were significantly associated with CDR deterioration. Conclusion Memory dysfunction and decreased activity during the COVID-19 pandemic are strongly related to the deterioration of cognitive impairment. Psychiatry Investig 2023;20(2):109-119
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