12-OAHSA is a component of olive oil and mitigates obesity-induced inflammation
DC Field | Value | Language |
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dc.contributor.author | Moyo, Knowledge Mudhibadhi | - |
dc.contributor.author | Choi, Jieun | - |
dc.contributor.author | Chang, Jiyeon | - |
dc.contributor.author | Soedono, Shindy | - |
dc.contributor.author | Nguyet, Dan Vo Hoang | - |
dc.contributor.author | Song, Yu-Ri | - |
dc.contributor.author | Park, Soo Jin | - |
dc.contributor.author | Go, Gwang-Woong | - |
dc.contributor.author | Lee, Do Yup | - |
dc.contributor.author | Cho, Kae Won | - |
dc.date.accessioned | 2023-05-25T01:41:51Z | - |
dc.date.available | 2023-05-25T01:41:51Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 0955-2863 | - |
dc.identifier.issn | 1873-4847 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22459 | - |
dc.description.abstract | Fatty acid esters of hydroxyl fatty acids (FAHFAs) are a new family of endogenous lipids that exert anti-inflammatory action. Among the various FAHFA isomers, the dietary source of oleic acid-hydroxy stearic acid (OAHSA) and its anti-inflammatory functions are poorly understood. This study investigated the composition of OAHSA isomers in dietary oils and the impact of 12-OAHSA on obesity-induced inflammation. Liquid chromatography with tandem mass spectrometry analysis revealed that various dietary oils, including fish oil, corn oil, palm oil, soybean oil, and olive oil, present a wide variation in OAHSA profiles and amounts. The highest amounts of total OAHSAs are present in olive oil including 12-OAHSA. Compared to vehicle-treated obese mice, administration of 12-OAHSA significantly improved glucose homeostasis, independent of body weight. 12-OAHSA-treated mice displayed significantly reduced accumulation of CD11c(+) adipose tissue macrophages, and CD4(+) /CD8(+) adipose tissue T lymphocytes. Concomitantly, the expression of pro-inflammatory cytokine genes and the nuclear factor kappa-light-chain-enhancer of activated B cells signaling pathway were significantly decreased in the 12-OAHSA-treated adipose tissue, while the expression of the anti-inflammatory gene Il10 was markedly increased. Moreover, in vitro cell culture experiments showed that 12-OAHSA significantly inhibited the lipopolysaccharides-induced inflammatory response in macrophages by suppressing the nuclear factor kappa-light-chainenhancer of activated B cells signaling pathway. Collectively, these results indicated that 12-OAHSA, as a component of olive oil, mitigates obesity-induced insulin resistance by regulating AT inflammation. Therefore, 12-OAHSA could be used as a novel nutritional intervention against obesity-associated metabolic dysregulation. (C) 2022 Elsevier Inc. All rights reserved. | - |
dc.publisher | Elsevier BV | - |
dc.title | 12-OAHSA is a component of olive oil and mitigates obesity-induced inflammation | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.jnutbio.2022.109127 | - |
dc.identifier.scopusid | 2-s2.0-85137735354 | - |
dc.identifier.wosid | 000878611700002 | - |
dc.identifier.bibliographicCitation | Journal of Nutritional Biochemistry, v.110 | - |
dc.citation.title | Journal of Nutritional Biochemistry | - |
dc.citation.volume | 110 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | FATTY-ACIDS FAHFAS | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | ESTERS | - |
dc.subject.keywordPlus | LIPIDS | - |
dc.subject.keywordAuthor | FAHFA | - |
dc.subject.keywordAuthor | LC-MS/MS | - |
dc.subject.keywordAuthor | 12-OAHSA | - |
dc.subject.keywordAuthor | Olive oil | - |
dc.subject.keywordAuthor | Adipose tissue inflammation | - |
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