Comparison of 3-to 6-Month Versus 12-Month Dual Antiplatelet Therapy After Coronary Intervention Using the Contemporary Drug-Eluting Stents With Ultrathin Struts: The HOST-IDEA Randomized Clinical Trial
DC Field | Value | Language |
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dc.contributor.author | Han, Jung-Kyu | - |
dc.contributor.author | Hwang, Doyeon | - |
dc.contributor.author | Yang, Seokhun | - |
dc.contributor.author | Park, Sang-Hyeon | - |
dc.contributor.author | Kang, Jeehoon | - |
dc.contributor.author | Yang, Han-Mo | - |
dc.contributor.author | Park, Kyung Woo | - |
dc.contributor.author | Kang, Hyun-Jae | - |
dc.contributor.author | Koo, Bon-Kwon | - |
dc.contributor.author | Hur, Seung-Ho | - |
dc.contributor.author | Kim, Weon | - |
dc.contributor.author | Kim, Seok Yeon | - |
dc.contributor.author | Park, Sang-Hyun | - |
dc.contributor.author | Han, Seung Hwan | - |
dc.contributor.author | Kim, Sang-Hyun | - |
dc.contributor.author | Shin, Sanghoon | - |
dc.contributor.author | Kim, Yong Hoon | - |
dc.contributor.author | Park, Kyungil | - |
dc.contributor.author | Lee, Namho | - |
dc.contributor.author | Lee, Seung Jin | - |
dc.contributor.author | Kim, Jin Won | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.date.accessioned | 2023-12-11T09:32:51Z | - |
dc.date.available | 2023-12-11T09:32:51Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 0009-7322 | - |
dc.identifier.issn | 1524-4539 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22850 | - |
dc.description.abstract | BACKGROUND: Limited data are available on short-term dual antiplatelet therapy (DAPT) after percutaneous coronary intervention using third-generation drug-eluting stents with ultrathin struts and advanced polymer technology. We investigated whether 3- to 6-month DAPT was noninferior to 12-month DAPT after implantation of drug-eluting stents with ultrathin struts and advanced polymer technology. METHODS: We performed an open-label, randomized trial at 37 centers in South Korea. We enrolled patients undergoing percutaneous coronary intervention using the Orsiro biodegradable-polymer sirolimus-eluting stents or the Coroflex ISAR polymerfree sirolimus-eluting stents. Patients with ST-segment-elevation myocardial infarction were excluded. Patients were randomly assigned to receive either 3- to 6-month or 12-month DAPT after percutaneous coronary intervention. The choice of antiplatelet medications was at the physician's discretion. The primary outcome was a net adverse clinical event, a composite of cardiac death, target vessel myocardial infarction, clinically driven target lesion revascularization, stent thrombosis, or major bleeding, defined as Bleeding Academic Research Consortium type 3 or 5 at 12 months. The major secondary outcomes were target lesion failure, a composite of cardiac death, target vessel myocardial infarction, clinically driven target lesion revascularization, and major bleeding. RESULTS: A total of 2013 patients (mean age, 65.7 +/- 10.5 years; 1487 males [73.9%]; 1110 [55.1%] presented with acute coronary syndrome) were randomly assigned to 3- to 6-month DAPT (n=1002) or 12-month DAPT (n=1011). The primary outcome occurred in 37 (3.7%) patients in the 3- to 6-month DAPT group and 41 (4.1%) in the 12-month DAPT group. The noninferiority of the 3- to 6-month DAPT group to the 12-month DAPT group was met (absolute risk difference, -0.4% [1-sided 95% CI, -8% to 1.1%]; P < 0.001 for noninferiority). There were no significant differences in target lesion failure (hazard ratio, 0.98 [95% CI, 0.56-1.71], P=0.94) or major bleeding (hazard ratio, 0.82 [95% CI, 0.41-1.61], P=0.56) between the 2 groups. Across various subgroups, the treatment effect of 3- to 6-month DAPT was consistent for net adverse clinical event. CONCLUSIONS: Among patients undergoing percutaneous coronary intervention using third-generation drug-eluting stents, 3to 6-month DAPT was noninferior to 12-month DAPT for net adverse clinical event. Further research is needed to generalize this finding to other populations and to determine the ideal regimen for 3- to 6-month DAPT. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | Comparison of 3-to 6-Month Versus 12-Month Dual Antiplatelet Therapy After Coronary Intervention Using the Contemporary Drug-Eluting Stents With Ultrathin Struts: The HOST-IDEA Randomized Clinical Trial | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1161/CIRCULATIONAHA.123.064264 | - |
dc.identifier.scopusid | 2-s2.0-85158042851 | - |
dc.identifier.wosid | 000978842200003 | - |
dc.identifier.bibliographicCitation | Circulation, v.147, no.18, pp 1358 - 1368 | - |
dc.citation.title | Circulation | - |
dc.citation.volume | 147 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 1358 | - |
dc.citation.endPage | 1368 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | 2011 ACCF/AHA/SCAI GUIDELINE | - |
dc.subject.keywordPlus | ASSOCIATION TASK-FORCE | - |
dc.subject.keywordPlus | ARTERY-DISEASE | - |
dc.subject.keywordPlus | CARDIOVASCULAR EVENTS | - |
dc.subject.keywordPlus | AMERICAN-COLLEGE | - |
dc.subject.keywordPlus | FOCUSED UPDATE | - |
dc.subject.keywordPlus | MONOTHERAPY | - |
dc.subject.keywordPlus | IMPLANTATION | - |
dc.subject.keywordPlus | ASPIRIN | - |
dc.subject.keywordPlus | DEFINITIONS | - |
dc.subject.keywordAuthor | aspirin | - |
dc.subject.keywordAuthor | dual anti-platelet therapy | - |
dc.subject.keywordAuthor | drug-eluting stents | - |
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