Tat-indoleamine 2,3-dioxygenase 1 elicits neuroprotective effects on ischemic injury
DC Field | Value | Language |
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dc.contributor.author | Park, Jung Hwan | - |
dc.contributor.author | Kim, Dae Won | - |
dc.contributor.author | Shin, Min Jea | - |
dc.contributor.author | Park, Jinseu | - |
dc.contributor.author | Han, Kyu Hyung | - |
dc.contributor.author | Lee, Keun Wook | - |
dc.contributor.author | Park, Jong Kook | - |
dc.contributor.author | Choi, Yeon Joo | - |
dc.contributor.author | Yeo, Hyeon Ji | - |
dc.contributor.author | Yeo, Eun Ji | - |
dc.contributor.author | Sohn, Eun Jeong | - |
dc.contributor.author | Kim, Hyoung-Chun | - |
dc.contributor.author | Shin, Eun-Joo | - |
dc.contributor.author | Cho, Sung-Woo | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.contributor.author | Cho, Yong-Jun | - |
dc.contributor.author | Eum, Won Sik | - |
dc.contributor.author | Choi, Soo Young | - |
dc.date.accessioned | 2021-08-11T08:31:35Z | - |
dc.date.available | 2021-08-11T08:31:35Z | - |
dc.date.issued | 2020-11-30 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2309 | - |
dc.description.abstract | It is well known that oxidative stress participates in neuronal cell death caused production of reactive oxygen species (ROS). The increased ROS is a major contributor to the development of ischemic injury. Indoleamine 2,3-dioxygenase 1 (IDO-1) is involved in the kynurenine pathway in tryptophan metabolism and plays a role as an anti-oxidant. However, whether IDO-1 would inhibit hippocampal cell death is poorly known. Therefore, we explored the effects of cell permeable Tat-IDO-1 protein against oxidative stress-induced HT-22 cells and in a cerebral ischemia/reperfusion injury model. Transduced Tat-IDO-1 reduced cell death, ROS production, and DNA fragmentation and inhibited mitogen-activated protein kinases (MAPKs) activation in H2O2 exposed HT-22 cells. In the cerebral ischemia/ reperfusion injury model, Tat-IDO-1 transduced into the brain and passing by means of the blood-brain barrier (BBB) significantly prevented hippocampal neuronal cell death. These results suggest that Tat-IDO-1 may present an alternative strategy to improve from the ischemic injury. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | Tat-indoleamine 2,3-dioxygenase 1 elicits neuroprotective effects on ischemic injury | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5483/BMBRep.2020.53.11.114 | - |
dc.identifier.scopusid | 2-s2.0-85096888275 | - |
dc.identifier.wosid | 000595589500004 | - |
dc.identifier.bibliographicCitation | BMB Reports, v.53, no.11, pp 582 - 587 | - |
dc.citation.title | BMB Reports | - |
dc.citation.volume | 53 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 582 | - |
dc.citation.endPage | 587 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002650362 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | TRANSIENT FOREBRAIN ISCHEMIA | - |
dc.subject.keywordPlus | CELL-PENETRATING PEPTIDES | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | REPERFUSION INJURY | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | QUINOLINIC ACID | - |
dc.subject.keywordPlus | IDO INDUCTION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Ischemia | - |
dc.subject.keywordAuthor | MAPKs | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Protein therapy | - |
dc.subject.keywordAuthor | Tat-IDO-1 | - |
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