Elevated CLOCK and BMAL1 Contribute to the Impairment of Aerobic Glycolysis from Astrocytes in Alzheimer's Disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, Ik Dong | - |
dc.contributor.author | Park, Min Woo | - |
dc.contributor.author | Cha, Hyeon Woo | - |
dc.contributor.author | Yoon, Sunmi | - |
dc.contributor.author | Boonpraman, Napissara | - |
dc.contributor.author | Yi, Sun Shin | - |
dc.contributor.author | Moon, Jong-Seok | - |
dc.date.accessioned | 2021-08-11T08:31:46Z | - |
dc.date.available | 2021-08-11T08:31:46Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2362 | - |
dc.description.abstract | Altered glucose metabolism has been implicated in the pathogenesis of Alzheimer's disease (AD). Aerobic glycolysis from astrocytes is a critical metabolic pathway for brain energy metabolism. Disturbances of circadian rhythm have been associated with AD. While the role of circadian locomotor output cycles kaput (CLOCK) and brain muscle ARNT-like1 (BMAL1), the major components in the regulation of circadian rhythm, has been identified in the brain, the mechanism by which CLOCK and BMAL1 regulates the dysfunction of astrocytes in AD remains unclear. Here, we show that the protein levels of CLOCK and BMAL1 are significantly elevated in impaired astrocytes of cerebral cortex from patients with AD. We demonstrate that the over-expression of CLOCK and BMAL1 significantly suppresses aerobic glycolysis and lactate production by the reduction in hexokinase 1 (HK1) and lactate dehydrogenase A (LDHA) protein levels in human astrocytes. Moreover, the elevation of CLOCK and BMAL1 induces functional impairment by the suppression of glial fibrillary acidic protein (GFAP)-positive filaments in human astrocytes. Furthermore, the elevation of CLOCK and BMAL1 promotes cytotoxicity by the activation of caspase-3-dependent apoptosis in human astrocytes. These results suggest that the elevation of CLOCK and BMAL1 contributes to the impairment of astrocytes by inhibition of aerobic glycolysis in AD. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Elevated CLOCK and BMAL1 Contribute to the Impairment of Aerobic Glycolysis from Astrocytes in Alzheimer's Disease | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/ijms21217862 | - |
dc.identifier.scopusid | 2-s2.0-85093918002 | - |
dc.identifier.wosid | 000588897800001 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.21, no.21 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 21 | - |
dc.citation.number | 21 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | BRAIN ENERGY-METABOLISM | - |
dc.subject.keywordPlus | CIRCADIAN CLOCK | - |
dc.subject.keywordPlus | GLUCOSE-METABOLISM | - |
dc.subject.keywordPlus | LACTATE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ATROPHY | - |
dc.subject.keywordPlus | BARRIER | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | HYPOMETABOLISM | - |
dc.subject.keywordAuthor | CLOCK | - |
dc.subject.keywordAuthor | BMAL1 | - |
dc.subject.keywordAuthor | aerobic glycolysis | - |
dc.subject.keywordAuthor | astrocytes | - |
dc.subject.keywordAuthor | Alzheimer&#8217 | - |
dc.subject.keywordAuthor | s disease | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.