Prognostic Relevance of HJURP Expression in Patients with Surgically Resected Colorectal Cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Dong Hyun | - |
dc.contributor.author | Woo, Jongsoo | - |
dc.contributor.author | Kim, Hyeongjoo | - |
dc.contributor.author | Kim, Soo Youn | - |
dc.contributor.author | Ji, Sanghee | - |
dc.contributor.author | Jaygal, Gunn | - |
dc.contributor.author | Ahn, Tae Sung | - |
dc.contributor.author | Kim, Han Jo | - |
dc.contributor.author | Kwak, Hyoung Jong | - |
dc.contributor.author | Kim, Chang-Jin | - |
dc.contributor.author | Baek, Moo-Jun | - |
dc.contributor.author | Jeong, Dongjun | - |
dc.date.accessioned | 2021-08-11T08:31:46Z | - |
dc.date.available | 2021-08-11T08:31:46Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2363 | - |
dc.description.abstract | HJURP is a key factor for CENP-A deposition and maintenance in centromeres. The role of mis-regulation of histone chaperones in cancer initiation and progression has been studied. However, its role in colorectal cancer is still unclear. In this study, we aimed to evaluate the expression of HJURP in 162 colorectal cancer tissue. To investigate the function of HJURP in the colorectal cancer cell, we suppressed HJURP expression by siRNA and confirmed proliferation, migration, invasion, and anchorage independent of colony forming ability. The association between HJURP expression levels and clinicopathological factors was evaluated in 162 CRC tissues using immunohistochemistry. The overall survival rate in patients of HJURP high expression was higher than those in HJURP low expression in CRC. Suppressing HJURP expression decreased cellular proliferation, invasion, and migration in four CRC cell lines: HT29, HCT116, SW480, SW620 in vitro study. Our findings revealed that the knockdown of HJURP suppressed the proliferation, migration, invasion, and tumorigenicity in CRC cells. Due to its strong association with CRC, HJURP could be a potential prognostic biomarker and a novel target for drug discovery. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Prognostic Relevance of HJURP Expression in Patients with Surgically Resected Colorectal Cancer | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/ijms21217928 | - |
dc.identifier.scopusid | 2-s2.0-85094097879 | - |
dc.identifier.wosid | 000588979700001 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.21, no.21 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 21 | - |
dc.citation.number | 21 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | PLUS IRINOTECAN | - |
dc.subject.keywordPlus | CENP-A | - |
dc.subject.keywordPlus | LEUCOVORIN | - |
dc.subject.keywordPlus | FLUOROURACIL | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | Colorectal cancer (CRC) | - |
dc.subject.keywordAuthor | HJURP | - |
dc.subject.keywordAuthor | prognostic biomarker | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.