Clinical value of dual-phase F-18 sodium fluoride PET/CT for diagnosing bone metastasis in cancer patients with solitary bone lesion
DC Field | Value | Language |
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dc.contributor.author | Lee, Jeong Won | - |
dc.contributor.author | Park, Yong-Jin | - |
dc.contributor.author | Jeon, Youn Soo | - |
dc.contributor.author | Kim, Ki Hong | - |
dc.contributor.author | Lee, Jong Eun | - |
dc.contributor.author | Hong, Sung Hoon | - |
dc.contributor.author | Lee, Sang Mi | - |
dc.contributor.author | Jang, Su Jin | - |
dc.date.accessioned | 2021-08-11T08:32:26Z | - |
dc.date.available | 2021-08-11T08:32:26Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 2223-4292 | - |
dc.identifier.issn | 2223-4306 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2375 | - |
dc.description.abstract | Background: The present study aimed to investigate whether dual-phase F-18 sodium-fluoride (NaF) positron emission tomography/computed tomography (PET/CT) could improve the diagnostic accuracy of detecting bone metastasis in cancer patients with a solitary bone lesion compared to conventional F-18 NaF PET/CT. Methods: We retrospectively enrolled 113 cancer patients who underwent dual-phase F-18 NaF PET/CT for the differential diagnosis of a solitary bone lesion seen on bone scintigraphy. According to the dual phase PET/CT protocol, an early-phase scan was acquired immediately after radiotracer injection and a conventional F-18 NaF PET/CT scan was performed. The diagnostic abilities of the visual analysis of conventional and dual-phase PET/CT scans and two quantitative parameters (lesion-to-blood pool uptake ratio on early-phase scan and lesion-to-bone uptake ratio on conventional scan) for detecting bone metastasis were compared. The final diagnosis of bone metastasis was made by histopathological confirmation or follow-up imaging studies. Results: A metastatic bone lesion was diagnosed in 28 patients (24.8%). The sensitivity, specificity, and accuracy were 100.0%, 70.6%, and 77.9%, respectively, for visual analysis of conventional F-18 NaF PET/CT, 92.9%, 42.4%, 54.9%, respectively, for lesion-to-bone uptake ratio, 96.4%, 88.2%, and 90.3%, respectively, for visual analysis of dual-phase PET/CT, and 92.9%, 81.2%, and 83.2%, respectively, for lesion-to-blood pool uptake ratio. Visual analysis of dual-phase PET/CT was shown to have the highest area under the receiver operating characteristic curve value (0.923; 95% CI, 0.858-0.965) among all parameters. Conclusions: Dual-phase F-18 NaF PET/CT showed a high diagnostic ability for detecting bone metastasis with improved specificity and accuracy compared to conventional F-18 NaF PET/CT in cancer patients. Dual-phase F-18 NaF PET/CT might help diagnose bone metastasis in patients with malignancies who were shown to have a solitary bone lesion on bone scintigraphy. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ROOM 604 6-F HOLLYWOOD CENTER, 77-91, QUEENS ROAD, SHEUNG WAN, PEOPLES R CHINA, HONG KONG, 00000 | - |
dc.title | Clinical value of dual-phase F-18 sodium fluoride PET/CT for diagnosing bone metastasis in cancer patients with solitary bone lesion | - |
dc.type | Article | - |
dc.publisher.location | 중국 | - |
dc.identifier.doi | 10.21037/qims-20-607 | - |
dc.identifier.scopusid | 2-s2.0-85092154163 | - |
dc.identifier.wosid | 000573105100003 | - |
dc.identifier.bibliographicCitation | QUANTITATIVE IMAGING IN MEDICINE AND SURGERY, v.10, no.11, pp 2098 - 2111 | - |
dc.citation.title | QUANTITATIVE IMAGING IN MEDICINE AND SURGERY | - |
dc.citation.volume | 10 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2098 | - |
dc.citation.endPage | 2111 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | WHOLE-BODY SPECT/CT | - |
dc.subject.keywordPlus | F-18-FLUORIDE PET/CT | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | EMISSION TOMOGRAPHY | - |
dc.subject.keywordPlus | SPECT/SPIRAL CT | - |
dc.subject.keywordPlus | HOT-SPOT | - |
dc.subject.keywordPlus | SCINTIGRAPHY | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.subject.keywordPlus | EXPERIENCE | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordAuthor | Bone | - |
dc.subject.keywordAuthor | diagnosis | - |
dc.subject.keywordAuthor | F-18 Sodium-fluoride (NaF) | - |
dc.subject.keywordAuthor | metastasis | - |
dc.subject.keywordAuthor | positron emission tomography (PET) | - |
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