Prognostic and clinicopathological roles of programmed death-ligand 1 (PD-L1) expression in thymic epithelial tumors: A meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Koh, Hyun Min | - |
dc.contributor.author | Jang, Bo Gun | - |
dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Hyun, Chang Lim | - |
dc.date.accessioned | 2021-08-11T08:32:28Z | - |
dc.date.available | 2021-08-11T08:32:28Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 1759-7706 | - |
dc.identifier.issn | 1759-7714 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2380 | - |
dc.description.abstract | Background Programmed death-ligand 1 (PD-L1) is one of the immune checkpoint proteins, and plays an important role in the progression and microenvironment of cancer. PD-L1 expression has been associated with poor survival in many cancers. Several studies have also shown an association between PD-L1 expression and the prognosis of patients with thymic epithelial tumors (TETs). In this study, we systematically evaluated the prognostic and clinicopathological roles of PD-L1 expression in TETs. Methods We searched the literature through PubMed, Embase and Cochrane library and chose the eligible studies, and subsequently performed a meta-analysis to evaluate the prognostic and clinicopathological roles of PD-L1 expression in TETs. Results Six of the 75 articles found in the literature were selected. PD-L1 expression was significantly related to unfavorable overall survival (hazard ratio 1.52, 95% confidence interval [CI]: 1.01-2.30,P= 0.046) in TETs. PD-L1 expression was significantly associated with male gender (odds ratio [OR] 1.55, 95% CI: 1.08-2.22,P= 0.017) and higher Masaoka stage (OR 3.93, 95% CI: 2.44-6.32,P< 0.001). Conclusions PD-L1 expression was correlated with unfavorable prognosis in TETs, indicating PD-L1 expression could help determine the prognosis of TET patients. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Asia Pty Ltd | - |
dc.title | Prognostic and clinicopathological roles of programmed death-ligand 1 (PD-L1) expression in thymic epithelial tumors: A meta-analysis | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/1759-7714.13590 | - |
dc.identifier.scopusid | 2-s2.0-85090970059 | - |
dc.identifier.wosid | 000568870200001 | - |
dc.identifier.bibliographicCitation | Thoracic Cancer, v.11, no.11, pp 3086 - 3098 | - |
dc.citation.title | Thoracic Cancer | - |
dc.citation.volume | 11 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3086 | - |
dc.citation.endPage | 3098 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordAuthor | Meta-analysis | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | programmed death-ligand 1 | - |
dc.subject.keywordAuthor | thymic epithelial tumor | - |
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