Curcumin Enhances the Anticancer Effects of Binimetinib on Melanoma Cells by Inducing Mitochondrial Dysfunction and Cell Apoptosis with Necroptosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yoon Jin | - |
dc.contributor.author | Heo, Jae Young | - |
dc.contributor.author | Kim, Dong Sung | - |
dc.contributor.author | Choi, Yu Sung | - |
dc.contributor.author | Kim, Sooyoung | - |
dc.contributor.author | Nam, Hae Seon | - |
dc.contributor.author | Lee, Sang Han | - |
dc.contributor.author | Cho, Moon Kyun | - |
dc.date.accessioned | 2023-12-13T10:03:22Z | - |
dc.date.available | 2023-12-13T10:03:22Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 1013-9087 | - |
dc.identifier.issn | 2005-3894 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/24888 | - |
dc.description.abstract | Background: Recent studies suggest that MEK1/2 inhibitors, including binimetinib, significantly improve malignant melanoma (MM) patient survival. Growing evidence suggests that phytochemicals, especially curcumin, can overcome drug resistance in cancer cells through a variety of mechanisms. Objective: This study aims to examine curcumin's efficacy in vitro combined with binimetinib in human MM cells. Methods: We used 2D monolayer and 3D spheroid human epidermal melanocyte culture models, HEMn-MP (human epidermal melanocytes, neonatal, moderately pigmented), and two human MM cell lines, G361 and SK-MEL-2, to evaluate cell viability, proliferation, migration, death, and reactive oxygen species (ROS) production following single therapy treatment, with either curcumin or binimetinib, or a combination of both. Results: Compared to MM cells treated with single therapy, those with combination therapy showed significantly decreased cell viability and increased ROS production. We observed apoptosis following both single and combination therapies. However only those who had had combination therapy had necroptosis. Conclusion: Collectively, our data demonstrates that curcumin exerts significant synergistic anticancer effects on MM cells by inducing ROS and necroptosis when combined with binimetinib. Therefore, a strategy of adding curcumin to conventional anticancer agents holds promise for treating MM. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한피부과학회 | - |
dc.title | Curcumin Enhances the Anticancer Effects of Binimetinib on Melanoma Cells by Inducing Mitochondrial Dysfunction and Cell Apoptosis with Necroptosis | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5021/ad.22.200 | - |
dc.identifier.scopusid | 2-s2.0-85164277030 | - |
dc.identifier.wosid | 001012022700006 | - |
dc.identifier.bibliographicCitation | Annals of Dermatology, v.35, no.3, pp 217 - 228 | - |
dc.citation.title | Annals of Dermatology | - |
dc.citation.volume | 35 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 217 | - |
dc.citation.endPage | 228 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002964007 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | THIOREDOXIN | - |
dc.subject.keywordPlus | VEMURAFENIB | - |
dc.subject.keywordPlus | DABRAFENIB | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Binimetinib | - |
dc.subject.keywordAuthor | Curcumin | - |
dc.subject.keywordAuthor | Melanoma | - |
dc.subject.keywordAuthor | Necroptosis | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.