Biochemical Recurrence in Prostate Cancer Is Associated with the Composition of Lactobacillus: Microbiome Analysis of Prostatic Tissueopen access
- Authors
- Kim, Jae Heon; Seo, Hoonhee; Kim, Sukyung; Ul-Haq, Asad; Rahim, Md Abdur; Jo, Sujin; Song, Ho-Yeon; Song, Yun Seob
- Issue Date
- Jul-2023
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- prostate carcer; cancer stem cells; tumor microenvironment; biomarker; therapeutic targets; drug resistance; cancer prevention
- Citation
- International Journal of Molecular Sciences, v.24, no.13
- Journal Title
- International Journal of Molecular Sciences
- Volume
- 24
- Number
- 13
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25031
- DOI
- 10.3390/ijms241310423
- ISSN
- 1661-6596
1422-0067
- Abstract
- Many human pathologies, such as malignancy, are linked with specific bacteria and changes in the constituents of the microbiome. In order to examine the association between an imbalance of bacteria and prostate carcinoma, a comparison of the microbiomes present in patients with biochemical recurrence (BCR) or NO BCR (NBCR) was performed. Additionally, 16S rRNA-based next-generation sequencing was applied to identify the bacterial profiles within these tumors in terms of the bacteria and operational genes present. The percentage average taxonomic composition between the taxa indicated no difference between BCR and NBCR. In addition, alpha and beta diversity indices presented no distinction between the cohorts in any statistical method. However, taxonomic biomarker discovery indicated a relatively higher population of Lactobacillus in the NBCR group, and this finding was supported by PCR data. Along with that, differences in the operational activity of the bacterial genes were also determined. It is proposed that the biochemical recurrence was linked to the quantity of Lactobacillus present. The aim of this study was to investigate the microbiome involved in prostate carcinoma and the potential association between them.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Urology > 1. Journal Articles
- College of Medicine > Department of Microbiology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25031)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.