Ginseng intake and Alzheimer disease-specific cognition in older adults according to apolipoprotein epsilon 4 allele status
DC Field | Value | Language |
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dc.contributor.author | Lee, Boung Chul | - |
dc.contributor.author | Choe, Young Min | - |
dc.contributor.author | Suh, Guk-Hee | - |
dc.contributor.author | Choi, Ihn-Geun | - |
dc.contributor.author | Kim, Hyun Soo | - |
dc.contributor.author | Hwang, Jaeuk | - |
dc.contributor.author | Yi, Dahyun | - |
dc.contributor.author | Jhoo, Jin Hyeong | - |
dc.contributor.author | Kim, Jee Wook | - |
dc.date.accessioned | 2023-12-13T18:31:23Z | - |
dc.date.available | 2023-12-13T18:31:23Z | - |
dc.date.issued | 2023-04 | - |
dc.identifier.issn | 1663-4365 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25041 | - |
dc.description.abstract | Background: The probable association among ginseng intake, Alzheimer's disease (AD)-specific cognition, and apolipoprotein e4 (APOE4) remains poorly investigated. Hence, we examined the association between ginseng intake and AD-specific cognition in older adults under the moderating effect of APOE4 status. Methods: This study enrolled 160 adults aged 65-90years without dementia. All participants underwent comprehensive dietary and clinical assessments including ginseng intake, AD-related cognition (i.e., delayed episodic memory, as the earliest cognitive change in AD), and non-memory cognition for comparative purposes. Results: Ginseng intake was associated with higher delayed episodic memory, but not non-memory cognition, compared to no ginseng intake. The interaction between ginseng intake and APOE4 status had a significant effect on delayed episodic memory. Subgroup analyses showed that ginseng intake was associated with higher delayed episodic memory in the APOE4-negative but not the APOE4positive subgroup. The benefits of ginseng intake on delayed episodic memory were prominent in the high duration (=5 years) and midlife onset (< 65years) groups. Conclusion: Our study of older adults with no dementia suggests that ginseng intake (with high duration and midlife onset) had a beneficial effect on ADspecific cognitive decline, i.e., the delayed episodic memory. In addition, APOE4 status moderates the association between ginseng intake status and AD-specific cognitive decline. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Ginseng intake and Alzheimer disease-specific cognition in older adults according to apolipoprotein epsilon 4 allele status | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3389/fnagi.2023.1152626 | - |
dc.identifier.scopusid | 2-s2.0-85153512558 | - |
dc.identifier.wosid | 000978752600001 | - |
dc.identifier.bibliographicCitation | Frontiers in Aging Neuroscience, v.15 | - |
dc.citation.title | Frontiers in Aging Neuroscience | - |
dc.citation.volume | 15 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | NEUROPSYCHOLOGICAL ASSESSMENT | - |
dc.subject.keywordPlus | MEMORY IMPAIRMENT | - |
dc.subject.keywordPlus | EPISODIC MEMORY | - |
dc.subject.keywordPlus | KOREAN VERSION | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | CERAD | - |
dc.subject.keywordPlus | CONSORTIUM | - |
dc.subject.keywordPlus | ESTABLISH | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | GINTONIN | - |
dc.subject.keywordAuthor | ginseng | - |
dc.subject.keywordAuthor | cognition | - |
dc.subject.keywordAuthor | Alzheimer's disease | - |
dc.subject.keywordAuthor | apolipoprotein epsilon 4 | - |
dc.subject.keywordAuthor | memory | - |
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