In vitro and in vivo evaluation of Ca/P-hyaluronic acid/gelatin based novel dental plugs for one-step socket preservation
DC Field | Value | Language |
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dc.contributor.author | Kang, Hoe-Jin | - |
dc.contributor.author | Park, Seong-Su | - |
dc.contributor.author | Saleh, Tarek | - |
dc.contributor.author | Ahn, Kang-Min | - |
dc.contributor.author | Lee, Byong-Taek | - |
dc.date.accessioned | 2021-08-11T08:32:57Z | - |
dc.date.available | 2021-08-11T08:32:57Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 0264-1275 | - |
dc.identifier.issn | 1873-4197 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2515 | - |
dc.description.abstract | Teeth extraction is inevitable in the case of progressive or alveolar bone destructing chronic periodontitis. Unfortunately, the resulting bone defects may lead to many side effects. Here, we developed a novel dental-bone substitute to preserve the extraction socket for hemostasis and bone regeneration. Hyaluronic acid-gelatin hydrogel (HG) polymers, beta-tricalcium phosphate (TCP), and biphasic calcium phosphate (BCP) ceramics were fabricated using freeze-drying methods. The HG/TCP/BCP plug was prepared to be easily applied by pouring the mixture of HG and TCP into the shell-shaped mold, followed by placing the sponge type of BCP in the core portion of the mold compared to HG/TCP and collagen plugs. In vitro studies showed that HG/TCP and HG/TCP/BCP plugs were cytocompatible and could promote osteogenesis by upregulating the expressions of bone-related genes COL1, RUNX2, ALP, and OPN. The rabbit-femur defect model revealed that the implanted HG/TCP/BCP plug, which showed excellent hemostatic property, promote bone regeneration with a high rate of collagen distribution along with ALP and OPN expressions more than could the HG/TCP plug at 3 months after implantation, whereas the collagen plugs just filled with chondrocytes for cartilages formation. The HG/TCP/BCP plug should be considered for potential dental applications for one-step socket preservation. (c) 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | In vitro and in vivo evaluation of Ca/P-hyaluronic acid/gelatin based novel dental plugs for one-step socket preservation | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.matdes.2020.108891 | - |
dc.identifier.scopusid | 2-s2.0-85087166144 | - |
dc.identifier.wosid | 000569881300003 | - |
dc.identifier.bibliographicCitation | Materials & Design, v.194 | - |
dc.citation.title | Materials & Design | - |
dc.citation.volume | 194 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | BONE SUBSTITUTES | - |
dc.subject.keywordPlus | TOOTH EXTRACTION | - |
dc.subject.keywordPlus | COLLAGEN SPONGE | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | HYDROGEL | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | HEMORRHAGE | - |
dc.subject.keywordPlus | GRAFTS | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordAuthor | Dental bone substitute | - |
dc.subject.keywordAuthor | Socket preservation | - |
dc.subject.keywordAuthor | Bone regeneration | - |
dc.subject.keywordAuthor | Hemostat | - |
dc.subject.keywordAuthor | Calcium phosphate | - |
dc.subject.keywordAuthor | Hyaluronic acid-gelatin | - |
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