Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Eun-Ji | - |
dc.contributor.author | Kim, Hyun-Soo | - |
dc.contributor.author | Lee, Do-Hyoung | - |
dc.contributor.author | Kim, Su-Min | - |
dc.contributor.author | Yoon, Joon-Sup | - |
dc.contributor.author | Lee, Ji-Min | - |
dc.contributor.author | Im, Se Jin | - |
dc.contributor.author | Lee, Ho | - |
dc.contributor.author | Lee, Min-Woo | - |
dc.contributor.author | Lee, Chang-Woo | - |
dc.date.accessioned | 2023-12-13T23:32:03Z | - |
dc.date.available | 2023-12-13T23:32:03Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25164 | - |
dc.description.abstract | Brown adipose tissue (BAT) plays a pivotal role in maintaining body temperature and energy homeostasis. BAT dysfunction is associated with impaired metabolic health. Here, we show that Ssu72 phosphatase is essential for mRNA translation of genes required for thermogenesis in BAT. Ssu72 is found to be highly expressed in BAT among adipose tissue depots, and the expression level of Ssu72 is increased upon acute cold exposure. Mice lacking adipocyte Ssu72 exhibit cold intolerance during acute cold exposure. Mechanistically, Ssu72 deficiency alters cytosolic mRNA translation program through hyperphosphorylation of eIF2 alpha and reduces translation of mitochondrial oxidative phosphorylation (OXPHOS) subunits, resulting in mitochondrial dysfunction and defective thermogenesis in BAT. In addition, metabolic dysfunction in Ssu72-deficient BAT returns to almost normal after restoring Ssu72 expression. In summary, our findings demonstrate that cold-responsive Ssu72 phosphatase is involved in cytosolic translation of key thermogenic effectors via dephosphorylation of eIF2 alpha in brown adipocytes, providing insights into metabolic benefits of Ssu72. Brown adipose tissue (BAT) is a specialized thermogenic organ that undergoes high demands of protein synthesis during thermogenic adaptation. Here, the authors show that the cold responsive phosphatase Ssu72 is required for mRNA translation that affects thermogenic adaptation in BAT. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1038/s41467-023-36836-y | - |
dc.identifier.scopusid | 2-s2.0-85149033752 | - |
dc.identifier.wosid | 001002656000023 | - |
dc.identifier.bibliographicCitation | Nature Communications, v.14, no.1 | - |
dc.citation.title | Nature Communications | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | BROWN ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | UNFOLDED PROTEIN RESPONSE | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | BEIGE FAT | - |
dc.subject.keywordPlus | GLUCOSE-HOMEOSTASIS | - |
dc.subject.keywordPlus | INSULIN SENSITIVITY | - |
dc.subject.keywordPlus | MITOCHONDRIAL | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | OBESITY | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.