Spicy food intake predicts Alzheimer-related cognitive decline in older adults with low physical activity
DC Field | Value | Language |
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dc.contributor.author | Hwang, Jaeuk | - |
dc.contributor.author | Choe, Young Min | - |
dc.contributor.author | Suh, Guk-Hee | - |
dc.contributor.author | Lee, Boung Chul | - |
dc.contributor.author | Choi, Ihn-Geun | - |
dc.contributor.author | Lee, Jun Ho | - |
dc.contributor.author | Kim, Hyun Soo | - |
dc.contributor.author | Kim, Shin Gyeom | - |
dc.contributor.author | Yi, Dahyun | - |
dc.contributor.author | Kim, Jee Wook | - |
dc.date.accessioned | 2023-12-14T00:01:31Z | - |
dc.date.available | 2023-12-14T00:01:31Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25174 | - |
dc.description.abstract | A plausible association exists among spicy food consumption, physical activity, and Alzheimer's disease ( AD) or cognitive decline, but it remains poorly investigated. We aimed to examined the association between spicy food and AD-related memory decline or global cognitive decline in older adults under the moderating effect of physical activity. Total 196 non-demented older adults were included. Participants underwent comprehensive dietary and clinical assessments including spicy food intake, AD-related memory, global cognition, and physical activity. The strength of spicy food was stratified into three categories: `not spicy' (reference), `low spiciness', and `high spiciness'. Multiple linear regression analyses were performed to examine the relationships between spicy level and cognition. The spicy level was the independent variable in each analysis; it was entered as a stratified categorical variable using the three categories. We found a significant association between a high level of spiciness in food and decreased memory ( beta - 0.167, p < 0.001) or global cognition ( beta - 0.122, p = 0.027), but not non-memory cognition. To explore the moderating effects of age, sex, apolipoprotein E epsilon 4 allele-positivity, vascular risk score, body mass index, and physical activity on the associations between spicy level and memory or global cognition, the same regression analyses were repeated including two-way interaction terms between the spicy level and each of the six variables as an additional independent variable. An interactive effect was detected between a high level of spiciness in food and physical activity on the memory ( beta 0.209, p = 0.029) or global cognition ( beta 0.336, p = 0.001). Subgroup analyses showed that the association between a high level of spiciness in food and a lower memory ( beta - 0.254, p < 0.001) and global score ( beta - 0.222, p = 0.002) was present only in older adults with low physical activity, but not in older adults with high physical activity. Our findings suggest that spicy food intake is predictive of AD-related cognitive decline, i.e., episodic memory; this relationship is worsened by physically inactive lifestyle. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Spicy food intake predicts Alzheimer-related cognitive decline in older adults with low physical activity | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1038/s41598-023-35234-0 | - |
dc.identifier.scopusid | 2-s2.0-85159491933 | - |
dc.identifier.wosid | 000992335400004 | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.13, no.1 | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | NEUROPSYCHOLOGICAL ASSESSMENT BATTERY | - |
dc.subject.keywordPlus | MEMORY IMPAIRMENT | - |
dc.subject.keywordPlus | EPISODIC MEMORY | - |
dc.subject.keywordPlus | KOREAN VERSION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | CERAD | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | SCALE | - |
dc.subject.keywordPlus | NEUROTOXICITY | - |
dc.subject.keywordPlus | VALIDATION | - |
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