Comparison between Two-Dimensional and Point Shear Wave Elastography Techniques in Evaluating Liver Fibrosis Using Histological Staging as the Reference Standard: A Prospective Pilot Studyopen access
- Authors
- Lee, Sang Min; Ha, Hong Il; Lee, In Jae; Lee, Kwanseop; Lee, Jung Woo; Park, Ji Won; Kim, Sung-Eun; Kwon, Mi Jung; Choe, Ji-Young; Yoon, Sam-Youl; Yeo, Seung-Gu; Kim, Min-Jeong
- Issue Date
- May-2023
- Publisher
- MDPI AG
- Keywords
- two-dimensional shear wave elastography; point shear wave elastography; chronic liver disease; liver fibrosis; histology
- Citation
- Diagnostics, v.13, no.9
- Journal Title
- Diagnostics
- Volume
- 13
- Number
- 9
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25185
- DOI
- 10.3390/diagnostics13091646
- ISSN
- 2075-4418
- Abstract
- Evaluation of hepatic fibrosis is essential to prevent liver-related morbidity and mortality. Although various types of ultrasound shear wave elastography (SWE) have been used and validated, there are limited studies on the relatively newer technique, two-dimensional SWE (2D-SWE). Therefore, this study aimed to compare the diagnostic performances of 2D-SWE and point SWE (p-SWE) for evaluating liver fibrosis using histology as the reference standard. To measure liver stiffness (LS) values, 87 patients underwent 2D-SWE and p-SWE using the same machine. Technical failures and unreliable measurements were also evaluated. The diagnostic performances of 2D-SWE and p-SWE were compared using area under the receiver operating characteristic (AUROC) curve analysis. No technical failures were observed in either method; however, unreliable measurements were less frequent in 2D-SWE (1/87 [1.1%]) than in p-SWE (8/87 [9.2%]) (p < 0.001). The AUROC of the LS values of 2D-SWE were significantly higher than those of p-SWE for diagnosing significant fibrosis (0.965 vs. 0.872, p = 0.022) and cirrhosis (0.994 vs. 0.886, p = 0.042). In conclusion, 2D-SWE is more reliable and accurate than p-SWE for diagnosing hepatic fibrosis.
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Collections - College of Medicine > Department of Radiation Oncology > 1. Journal Articles
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