Consensus Definition of Blood Samples from the Subcategorized Normal Controls in the Korea Biobank Networkopen access
- Authors
- Han, Ji Eun; Park, Min Kyu; Jin, Ju Hyun; Lee, Jung Ah; Park, Gyeongsin; Park, Jong Sook; Bae, Han-Ik; Yun, Seok Joong; Seo, An Na; Han, Man-Hoon; Lee, Hyoungnam; Jeon, Jae-Pil; Yu, Ji-In; Kim, Soon Sun; Cheong, Jae Youn
- Issue Date
- Apr-2023
- Publisher
- MDPI AG
- Keywords
- control definition; healthy control; normal control; biospecimen; biobank; Korea Biobank Network
- Citation
- Journal of Clinical Medicine, v.12, no.9
- Journal Title
- Journal of Clinical Medicine
- Volume
- 12
- Number
- 9
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25312
- DOI
- 10.3390/jcm12093080
- ISSN
- 2077-0383
2077-0383
- Abstract
- A control group is defined as a group of people used for comparison. Depending on the type of study, it can be a group of healthy people or a group not exposed to risk factors. It is important to allow researchers to select the appropriate control participants. The Korea Biobank Project-sponsored biobanks are affiliated with the Korea Biobank Network (KBN), for which the National Biobank of Korea plays a central coordinating role among KBN biobanks. KBN organized several working groups to address new challenges and needs in biobanking. The "Normal Healthy Control Working Group" developed standardized criteria for three defined control groups, namely, normal, normal-plus, and disease-specific controls. Based on the consensus on the definition of a normal control, we applied the criteria for normal control participants to retrospective data. The main reason for exclusion from the "Normal-plus" group was blood test results beyond 5% of the reference range, including hypercholesterolemia. Subclassification of samples of normal controls by detailed criteria will help researchers select optimal normal controls for their studies.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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