The significance of programed cell death-ligand 1 expression in vestibular schwannoma
DC Field | Value | Language |
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dc.contributor.author | Lee, Se A. | - |
dc.contributor.author | Chin, Susie | - |
dc.contributor.author | Jung, Shin | - |
dc.contributor.author | Lee, Kyung-Hwa | - |
dc.contributor.author | Moon, Kyung-Sub | - |
dc.contributor.author | Lee, Jong Dae | - |
dc.date.accessioned | 2023-12-14T06:01:42Z | - |
dc.date.available | 2023-12-14T06:01:42Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 2162-3279 | - |
dc.identifier.issn | 2162-3279 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25325 | - |
dc.description.abstract | BackgroundThe association between programed cell death-ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) in vestibular schwannoma (VS) has been investigated in a few studies. These published studies report a difference in the PD-L1 positivity rate in malignant peripheral nerve sheath tumors. We examined PD-L1 expression and lymphocyte infiltration in patients with VS who had undergone surgical resection and investigated the association between PD-L1 expression and clinicopathological features. MethodsThe expression of PD-L1, CD8, and Ki-67 in 40 VS tissue specimens was investigated using immunohistochemistry, and a clinical review of the patients was performed. ResultsOf the 40 VS samples, 23 (57.5%) were positive for PD-L1 and 22 (55%) were positive for CD8. No significant differences in age, tumor size, pure-tone audiometry, speech discrimination, or Ki-67 expression were observed between patients in the PD-L1-positive and PD-L1-negative groups. A higher level of CD8-positive cell infiltration was observed in PD-L1-positive tumors than in PD-L1-negative tumors. ConclusionWe demonstrated that PD-L1 was expressed in VS tissues. Although no correlation was identified between clinical characteristics and PD-L1 expression, the association between PD-L1 and CD8 was confirmed. Thus, additional research on targeting PD-L1 is necessary to improve immunotherapy for VS in the future. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley and Sons Inc. | - |
dc.title | The significance of programed cell death-ligand 1 expression in vestibular schwannoma | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/brb3.3137 | - |
dc.identifier.scopusid | 2-s2.0-85162948660 | - |
dc.identifier.wosid | 001016763300001 | - |
dc.identifier.bibliographicCitation | Brain and Behavior, v.13, no.9 | - |
dc.citation.title | Brain and Behavior | - |
dc.citation.volume | 13 | - |
dc.citation.number | 9 | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Behavioral Sciences | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Behavioral Sciences | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | PD-L1 EXPRESSION | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | B7-H1 | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordAuthor | immunochemistry | - |
dc.subject.keywordAuthor | lymphocytes | - |
dc.subject.keywordAuthor | neuroma acoustic | - |
dc.subject.keywordAuthor | tumor-infiltrating | - |
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