The alternative bile acid pathway can predict food allergy persistence in early childhood
DC Field | Value | Language |
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dc.contributor.author | Lee, So-Yeon | - |
dc.contributor.author | Park, Yoon Mee | - |
dc.contributor.author | Yoo, Hyun Ju | - |
dc.contributor.author | Lee, Seung-Hwa | - |
dc.contributor.author | Choi, Eom Ji | - |
dc.contributor.author | Baek, Eun Young | - |
dc.contributor.author | Song, Geun baek | - |
dc.contributor.author | Yoon, Jisun | - |
dc.contributor.author | Hong, Soo-Jong | - |
dc.date.accessioned | 2023-12-14T06:31:05Z | - |
dc.date.available | 2023-12-14T06:31:05Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 0905-6157 | - |
dc.identifier.issn | 1399-3038 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25456 | - |
dc.description.abstract | BackgroundMechanisms underlying persistent food allergy (FA) are not well elucidated. The intestinal mucosa is the primary exposure route of food allergens. However, no study has examined intestinal metabolites associated with FA persistence. The goal of this study was to investigate intestinal metabolites and associated microbiomes in early life that aid in determining the development and persistence of FA. MethodsWe identified metabolomic alterations in the stool of infants according to FA by mass spectrometry-based untargeted metabolome profiling. The targeted metabolomic analysis of bile acid metabolites and stool microbiome was performed. Bile acid metabolite composition in infancy was evaluated by characterizing the subjects at the age of 3 into FA remission and persistent FA. ResultsIn untargeted metabolomics, primary bile acid biosynthesis was significantly different between subjects with FA and healthy controls. In targeted metabolomics for bile acids, intestinal bile acid metabolites synthesized by the alternative pathway were reduced in infants with FA than those in healthy controls. Subjects with persistent FA were also distinguished from healthy controls and those with FA remission by bile acid metabolites of the alternative pathway. These metabolites were negatively correlated with specific IgE levels in egg white. The abundance of intestinal Clostridia was decreased in the FA group and was correlated with ursodeoxycholic acid. ConclusionIntestinal bile acid metabolites of the alternative pathway could be predictive biomarkers for persistent FA in early childhood. These findings require replication in future studies. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | The alternative bile acid pathway can predict food allergy persistence in early childhood | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/pai.14003 | - |
dc.identifier.scopusid | 2-s2.0-85166417621 | - |
dc.identifier.wosid | 001040531500001 | - |
dc.identifier.bibliographicCitation | PEDIATRIC ALLERGY AND IMMUNOLOGY, v.34, no.8 | - |
dc.citation.title | PEDIATRIC ALLERGY AND IMMUNOLOGY | - |
dc.citation.volume | 34 | - |
dc.citation.number | 8 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | LIFE | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordAuthor | alternative pathway | - |
dc.subject.keywordAuthor | bile acids | - |
dc.subject.keywordAuthor | food allergy | - |
dc.subject.keywordAuthor | metabolomics | - |
dc.subject.keywordAuthor | microbiota | - |
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