Evaluating anti-thymocyte globulin induction doses for better allograft and patient survival in Asian kidney transplant recipients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shim, Ye Eun | - |
dc.contributor.author | Ko, Youngmin | - |
dc.contributor.author | Lee, Jung Pyo | - |
dc.contributor.author | Jeon, Jin Seok | - |
dc.contributor.author | Jun, Heungman | - |
dc.contributor.author | Yang, Jaeseok | - |
dc.contributor.author | Kim, Myoung Soo | - |
dc.contributor.author | Lim, Seong Jun | - |
dc.contributor.author | Kwon, Hye Eun | - |
dc.contributor.author | Jung, Joo Hee | - |
dc.contributor.author | Kwon, Hyunwook | - |
dc.contributor.author | Kim, Young Hoon | - |
dc.contributor.author | Lee, Jungbok | - |
dc.contributor.author | Shin, Sung | - |
dc.date.accessioned | 2023-12-14T06:31:12Z | - |
dc.date.available | 2023-12-14T06:31:12Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25470 | - |
dc.description.abstract | Anti-thymocyte globulin (ATG) is currently the most widely prescribed induction regimen for preventing acute rejection after solid organ transplantation. However, the optimal dose of ATG induction regimen in Asian kidney recipients is unclear. Using the Korean Organ Transplantation Registry, we performed a retrospective cohort study of 4579 adult patients who received renal transplantation in South Korea and divided them into three groups according to the induction regimen: basiliximab group (n = 3655), low-dose ATG group (& LE; 4.5 mg/kg; n = 467), and high-dose ATG group (> 4.5 mg/kg; n = 457). We applied the Toolkit for Weighting and Analysis of Nonequivalent Groups (TWANG) package to generate high-quality propensity score weights for intergroup comparisons. During four-year follow-ups, the high-dose ATG group had the highest biopsy-proven acute rejection rate (basiliximab 20.8% vs. low-dose ATG 22.4% vs. high-dose ATG 25.6%; P < 0.001). However, the rates of overall graft failure (4.0% vs. 5.0% vs. 2.6%; P < 0.001) and mortality (1.7% vs. 2.8% vs. 1.0%; P < 0.001) were the lowest in the high-dose ATG group. Our results show that high-dose ATG induction (> 4.5 mg/kg) was superior to basiliximab and low-dose ATG induction in terms of graft and patient survival in Asian patients undergoing kidney transplant. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Evaluating anti-thymocyte globulin induction doses for better allograft and patient survival in Asian kidney transplant recipients | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1038/s41598-023-39353-6 | - |
dc.identifier.scopusid | 2-s2.0-85166419821 | - |
dc.identifier.wosid | 001042088200022 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.13, no.1 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | RECEIVING MYCOPHENOLATE-MOFETIL | - |
dc.subject.keywordPlus | RABBIT ANTITHYMOCYTE GLOBULIN | - |
dc.subject.keywordPlus | LONG-TERM | - |
dc.subject.keywordPlus | RENAL-TRANSPLANTATION | - |
dc.subject.keywordPlus | NK CELLS | - |
dc.subject.keywordPlus | THYMOGLOBULIN | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | BASILIXIMAB | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | REJECTION | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.