Prevalence, incidence, and outcomes of hepatitis E virus coinfection in patients with chronic hepatitis C
DC Field | Value | Language |
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dc.contributor.author | Jang, Eun Sun | - |
dc.contributor.author | Choi, Gwang Hyeon | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Kim, In Hee | - |
dc.contributor.author | Lee, Youn Jae | - |
dc.contributor.author | Cho, Sung Beom | - |
dc.contributor.author | Kim, Yun-Tae | - |
dc.contributor.author | Jeong, Sook-Hyang | - |
dc.date.accessioned | 2023-12-14T06:31:47Z | - |
dc.date.available | 2023-12-14T06:31:47Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25576 | - |
dc.description.abstract | This study aimed to elucidate the anti-hepatitis E virus (HEV) immunoglobulin G (IgG) prevalence and incidence of seroconversion and seroreversion as well as its risk factors and to analyze the clinical outcomes of HEV and hepatitis C virus (HCV) coinfected patients compared to those of HCVmonoinfected patients. We prospectively enrolled 502 viremic HCV patients with paired plasma samples (at intervals of = 12 months) from 5 tertiary hospitals. Anti-HEV IgG positivity was tested using the Wantai ELISA kit in all paired samples. Mean age was 58.2 +/- 11.5 years old, 48.2% were male, 29.9% of patients had liver cirrhosis, and 9.4% of patients were diagnosed with hepatocellular carcinoma (HCC). The overall prevalence of anti-HEV IgG positivity at enrollment was 33.3%, with a higher prevalence in males and increasing prevalence according to the subject's age. During the 916.4 person-year, the HEV incidence rate was 0.98/100 person-years (9/335, 2.7%). Hepatic decompensation or liver-related mortality was not observed. There were six seroreversion cases among 172 anti-HEV-positive patients (1.22/100 person-years). In conclusion, approximately onethird of the adult Korean chronic HCV patients were anti-HEV IgG positive. The HEV incidence rate was 1 in 100 persons per year, without adverse hepatic outcomes or mortality. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Prevalence, incidence, and outcomes of hepatitis E virus coinfection in patients with chronic hepatitis C | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1038/s41598-023-39019-3 | - |
dc.identifier.scopusid | 2-s2.0-85168509909 | - |
dc.identifier.wosid | 001054205700045 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.13, no.1 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | VIRAL-HEPATITIS | - |
dc.subject.keywordPlus | B-VIRUS | - |
dc.subject.keywordPlus | SEROPREVALENCE | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | SUPERINFECTION | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | HEV | - |
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