Etiology and clinical characteristics of acute viral hepatitis in South Korea during 2020-2021: a prospective multicenter study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Chan Young | - |
dc.contributor.author | Choi, Gwang Hyeon | - |
dc.contributor.author | Jang, Eun Sun | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Lee, Youn-Jae | - |
dc.contributor.author | Kim, In Hee | - |
dc.contributor.author | Cho, Sung Bum | - |
dc.contributor.author | Yoon, Jae Hyun | - |
dc.contributor.author | Kim, Kyung-Ah | - |
dc.contributor.author | Choi, Dae Hee | - |
dc.contributor.author | Chung, Woo Jin | - |
dc.contributor.author | Cho, Hyun-Jin | - |
dc.contributor.author | Na, Seong Kyun | - |
dc.contributor.author | Kim, Yun-Tae | - |
dc.contributor.author | Lee, Byung Seok | - |
dc.contributor.author | Jeong, Sook-Hyang | - |
dc.date.accessioned | 2023-12-14T06:31:49Z | - |
dc.date.available | 2023-12-14T06:31:49Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25584 | - |
dc.description.abstract | This prospective, 12-center study investigated the etiology and clinical characteristics of acute viral hepatitis (AVH) during 2020-2021 in South Korea, and the performance of different diagnostic methods for hepatitis E virus (HEV). We enrolled 428 patients with acute hepatitis, of whom 160 (37.4%) were diagnosed with AVH according to predefined serologic criteria. The clinical data and risk factors for AVH were analyzed. For hepatitis E patients, anti-HEV IgM and IgG were tested with two commercial ELISA kits (Abia and Wantai) with HEV-RNA real-time RT-PCR. HAV, HEV, HBV, HCV, Epstein-Barr virus (EBV), cytomegalovirus, and herpes simplex virus accounted for AVH in 78.8% (n = 126), 7.5% (n = 12), 3.1% (n = 5), 1.9% (n = 3), 6.9% (n = 11), 1.2% (n = 2), and 0.6% (n = 1) of 160 patients (median age, 43 years; men, 52.5%; median ALT, 2144 IU/L), respectively. Hospitalization, hemodialysis, and intensive care unit admission were required in 137 (86.7%), 5 (3.2%), and 1 (0.6%) patient, respectively. Two patients developed acute liver failure (1.3%), albeit without mortality or liver transplantation. Ingestion of uncooked clams/oysters and wild boars' blood/bile was reported in 40.5% and 16.7% of patients with HAV and HEV, respectively. The concordance rate between the anti-HEV-IgM results of both ELISA kits was 50%. HEV RNA was detected in only 17% of patients with HEV. The diagnosis of HEV needs clinical consideration due to incomplete HEV diagnostics. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Etiology and clinical characteristics of acute viral hepatitis in South Korea during 2020-2021: a prospective multicenter study | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1038/s41598-023-40775-5 | - |
dc.identifier.scopusid | 2-s2.0-85169338222 | - |
dc.identifier.wosid | 001059852100073 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.13, no.1 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | E VIRUS | - |
dc.subject.keywordPlus | DIAGNOSTIC PERFORMANCE | - |
dc.subject.keywordPlus | IGM | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.