Effect of delayed hospitalization on patients with non-ST-segment elevation myocardial infarction and complex lesions undergoing successful new-generation drug-eluting stents implantationopen access
- Authors
- Kim, Yong Hoon; Her, Ae-Young; Rha, Seung-Woon; Choi, Cheol Ung; Choi, Byoung Geol; Kim, Ji Bak; Park, Soohyung; Kang, Dong Oh; Park, Ji Young; Choi, Woong Gil; Park, Sang-Ho; Jeong, Myung Ho
- Issue Date
- Sep-2023
- Publisher
- NATURE PORTFOLIO
- Citation
- SCIENTIFIC REPORTS, v.13, no.1
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 13
- Number
- 1
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25662
- DOI
- 10.1038/s41598-023-43385-3
- ISSN
- 2045-2322
- Abstract
- In the absence of available data, we evaluated the effects of delayed hospitalization (symptom-to-door time [SDT] >= 24 h) on major clinical outcomes after new-generation drug-eluting stent implantation in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and complex lesions. In total, 4373 patients with NSTEMI were divided into complex (n = 2106) and non-complex (n = 2267) groups. The primary outcome was the 3-year rate of major adverse cardiac events (MACE), defined as all-cause death, recurrent MI, and any repeat revascularization. Secondary outcomes included the individual MACE components. In the complex group, all-cause death (adjusted hazard ratio [aHR], 1.752; p = 0.004) and cardiac death (aHR, 1.966; p = 0.010) rates were significantly higher for patients with SDT >= 24 h than for those with SDT < 24 h. In the non-complex group, all patients showed similar clinical outcomes. Patients with SDT < 24 h (aHR, 1.323; p = 0.031) and those with SDT >= 24 h (aHR, 1.606; p = 0.027) showed significantly higher rates of any repeat revascularization and all-cause death, respectively, in the complex group than in the non-complex group. Thus, in the complex group, delayed hospitalization was associated with higher 3-year mortalities.
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