Complementary modulation of BMP signaling improves bone healing efficiency
DC Field | Value | Language |
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dc.contributor.author | Fan, Jiabing | - |
dc.contributor.author | Zhang, Xiao | - |
dc.contributor.author | Kang, Minjee | - |
dc.contributor.author | Kim, Lauren | - |
dc.contributor.author | Lee, Chung-Sung | - |
dc.contributor.author | Hadaya, Danny | - |
dc.contributor.author | Aghaloo, Tara L. | - |
dc.contributor.author | Lee, Min | - |
dc.date.accessioned | 2024-01-26T05:31:27Z | - |
dc.date.available | 2024-01-26T05:31:27Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.issn | 1878-5905 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25889 | - |
dc.description.abstract | The bone morphogenetic protein (BMP) signaling pathway plays a crucial role in bone development and regeneration. While BMP-2 is widely used as an alternative to autograft, its clinical application has raised concerns about adverse side effects and deteriorated bone quality. Therefore, there is a need to develop more sophisticated approaches to regulate BMP signaling and promote bone regeneration. Here, we present a novel complementary strategy that targets both BMP antagonist noggin and agonist Trb3 to enhance bone defect repair without the application of exogenous BMP-2. In vitro studies showed that overexpression of Trb3 with simultaneous noggin suppression significantly promotes osteogenic differentiation of mesenchymal stem cells. This was accompanied by increased BMP/Smad signaling. We also developed sterosome nanocarriers, a nonphospholipid liposomal system, to achieve non-viral mediated noggin suppression and Trb3 overexpression. The gene-loaded sterosomes were integrated onto an apatite-coated polymer scaffold for in vivo calvarial defect implantation, resulting in robust bone healing compared to BMP-2 treatments. Our work provides a promising alternative for high-quality bone formation by regulating expression of BMP agonists and antagonists. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Complementary modulation of BMP signaling improves bone healing efficiency | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.biomaterials.2023.122335 | - |
dc.identifier.scopusid | 2-s2.0-85171758230 | - |
dc.identifier.wosid | 001083923900001 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.302 | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 302 | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | ADIPOCYTE DIFFERENTIATION | - |
dc.subject.keywordPlus | LIPOSOMES | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | TRB3 | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | NOGGIN | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | OSTEOGENESIS | - |
dc.subject.keywordAuthor | Noggin | - |
dc.subject.keywordAuthor | Trb3 | - |
dc.subject.keywordAuthor | BMP signaling | - |
dc.subject.keywordAuthor | Sterosome | - |
dc.subject.keywordAuthor | Bone repair | - |
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