Anti-biofilm and anti-virulence effects of zerumbone against Acinetobacter baumannii
DC Field | Value | Language |
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dc.contributor.author | Kim, Hye-Rim | - |
dc.contributor.author | Shin, Seul | - |
dc.contributor.author | Jang, Hye-In | - |
dc.contributor.author | Eom, Yong-Bin | - |
dc.date.accessioned | 2021-08-11T08:34:02Z | - |
dc.date.available | 2021-08-11T08:34:02Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 1350-0872 | - |
dc.identifier.issn | 1465-2080 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2591 | - |
dc.description.abstract | Acinetobacter baumannii is a multidrug-resistant opportunistic pathogen that affects patients with a compromised immune system and is becoming increasingly important as a hospital-derived infection. This pathogen is difficult to treat owing to its intrinsic multidrug resistance and ability to form antimicrobial-tolerant biofilms. In the present study, we aimed to assess the potential use of zerumbone as a novel anti-biofilm and/or anti-virulence agent against A. baumannii. The results showed that zerumbone at sub-inhibitory doses decreased biofilm formation and disrupted established A. baumannii biofilms. The zerumbone-induced decrease in biofilm formation was dose-dependent based on the results of microtitre plate biofilm assays and confocal laser scanning microscopy. In addition, our data validated the anti-virulence efficacy of zerumbone, wherein it significantly interfered with the motility of A. baumannii. To support these phenotypic results, transcriptional analysis revealed that zerumbone downregulated the expression of biofilm- and virulence-associated genes (adeA, adeB, adeC and bap) in A. baumannii. Overall, our findings suggested that zerumbone might be a promising bioactive agent for the treatment of biofilm- and virulence-related infections caused by multidrug-resistant A. baumannii. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Society for General Microbiology | - |
dc.title | Anti-biofilm and anti-virulence effects of zerumbone against Acinetobacter baumannii | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1099/mic.0.000930 | - |
dc.identifier.scopusid | 2-s2.0-85090027092 | - |
dc.identifier.wosid | 000579701800005 | - |
dc.identifier.bibliographicCitation | Microbiology, v.166, no.8, pp 717 - 726 | - |
dc.citation.title | Microbiology | - |
dc.citation.volume | 166 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 717 | - |
dc.citation.endPage | 726 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | EFFLUX PUMP ADEABC | - |
dc.subject.keywordPlus | CANDIDA-ALBICANS | - |
dc.subject.keywordPlus | STAPHYLOCOCCUS-AUREUS | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | BACTERIAL | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | ANTIBIOTICS | - |
dc.subject.keywordPlus | INFECTIONS | - |
dc.subject.keywordAuthor | Acinetobacter baumannii | - |
dc.subject.keywordAuthor | anti-biofilm | - |
dc.subject.keywordAuthor | anti-virulence | - |
dc.subject.keywordAuthor | biofilm-associated protein (Bap) | - |
dc.subject.keywordAuthor | resistance-nodulation-division (RND)-type efflux pump | - |
dc.subject.keywordAuthor | zerumbone | - |
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