Clinical Usefulness of a Cell-based Assay for Detecting Myelin Oligodendrocyte Glycoprotein Antibodies in Central Nervous System Inflammatory Disorders
DC Field | Value | Language |
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dc.contributor.author | Seok, Jin Myoung | - |
dc.contributor.author | Waters, Patrick | - |
dc.contributor.author | Jeon, Mi Young | - |
dc.contributor.author | Lee, Hye Lim | - |
dc.contributor.author | Baek, Seol-Hee | - |
dc.contributor.author | Park, Jin-Sung | - |
dc.contributor.author | Kang, Sa-Yoon | - |
dc.contributor.author | Kwon, Ohyun | - |
dc.contributor.author | Oh, Jeeyoung | - |
dc.contributor.author | Kim, Byung-Jo | - |
dc.contributor.author | Park, Kyung-Ah | - |
dc.contributor.author | Oh, Sei Yeul | - |
dc.contributor.author | Kim, Byoung Joon | - |
dc.contributor.author | Min, Ju-Hong | - |
dc.date.accessioned | 2024-06-11T07:03:01Z | - |
dc.date.available | 2024-06-11T07:03:01Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 2234-3806 | - |
dc.identifier.issn | 2234-3814 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26010 | - |
dc.description.abstract | Background: The clinical implications of myelin oligodendrocyte glycoprotein autoantibodies (MOG-Abs) are increasing. Establishing MOG-Ab assays is essential for effectively treating patients with MOG-Abs. We established an in-house cell-based assay (CBA) to detect MOG-Abs to identify correlations with patients' clinical characteristics. Methods: We established the CBA using HEK 293 cells transiently overexpressing fulllength human MOG, tested it against 166 samples from a multicenter registry of central nervous system (CNS) inflammatory disorders, and compared the results with those of the Oxford MOG-Ab-based CBA and a commercial MOG-Ab CBA kit. We recruited additional patients with MOG-Abs and compared the clinical characteristics of MOG-Ab-associated disease (MOGAD) with those of neuromyelitis optica spectrum disorder (NMOSD). Results: Of 166 samples tested, 10 tested positive for MOG-Abs, with optic neuritis (ON) being the most common manifestation (4/15, 26.7%). The in-house and Oxford MOG-Ab CBAs agreed for 164/166 (98.8%) samples (kappa= 0.883, P < 0.001); two patients (2/166, 1.2%) were only positive in our in-house CBA, and the CBA scores of the two laboratories correlated well (r=0.663, P < 0.001). The commercial MOG-Ab CBA kit showed one false negative and three false-positive results. The clinical presentation at disease onset differed between MOGAD and NMOSD; ON was the most frequent manifestation in MOGAD, and transverse myelitis was most frequent in NMOSD. Conclusions: The in-house CBA for MOG-Abs demonstrated reliable results and can potentially be used to evaluate CNS inflammatory disorders. A comprehensive, long-term study with a large patient population would clarify the clinical significance of MOG-Abs. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC LABORATORY MEDICINE | - |
dc.title | Clinical Usefulness of a Cell-based Assay for Detecting Myelin Oligodendrocyte Glycoprotein Antibodies in Central Nervous System Inflammatory Disorders | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3343/alm.2024.44.1.56 | - |
dc.identifier.scopusid | 2-s2.0-85169651534 | - |
dc.identifier.wosid | 001074354500008 | - |
dc.identifier.bibliographicCitation | ANNALS OF LABORATORY MEDICINE, v.44, no.1, pp 56 - 63 | - |
dc.citation.title | ANNALS OF LABORATORY MEDICINE | - |
dc.citation.volume | 44 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 56 | - |
dc.citation.endPage | 63 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART003024424 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.subject.keywordPlus | OPTICA SPECTRUM DISORDERS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | Autoantibody | - |
dc.subject.keywordAuthor | Central nervous system disease | - |
dc.subject.keywordAuthor | Immunoassay | - |
dc.subject.keywordAuthor | Myelin oligo-dendrocyte glycoprotein | - |
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