PM<sub>10</sub> increases mortality risk in rheumatoid arthritis-associated interstitial lung disease
DC Field | Value | Language |
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dc.contributor.author | Kim, Soo Han | - |
dc.contributor.author | Kim, Sun-Young | - |
dc.contributor.author | Yoon, Hee-Young | - |
dc.contributor.author | Song, Jin Woo | - |
dc.date.accessioned | 2024-06-11T07:32:26Z | - |
dc.date.available | 2024-06-11T07:32:26Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 2056-5933 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26044 | - |
dc.description.abstract | Objectives The effect of air pollution on the prognosis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) remains poorly understood. We aimed to evaluate the effect of long-term exposure to particulate matter with an aerodynamic diameter of <= 10 mu m (PM10) and nitrogen dioxide (NO2) on mortality in patients with RA-ILD. Methods We included 309 patients (mean age, 61.7 years; male, 44.3%) with RA-ILD. Individual-level long-term exposures to PM10 and NO2 at their residential addresses were estimated using a national-scale exposure prediction model. The effect of the two air pollutants on mortality was estimated using a Cox-proportional hazards model adjusted for individual-level and area-level characteristics. Results The median follow-up period was 4.8 years, and 40.8% of patients died or underwent lung transplantation. The annual average concentrations of PM10 and NO2 were 56.3 mu g/m(3) and 22.4 ppb, respectively. When air pollutant levels were stratified by quartiles, no association was observed between air pollutant concentration and mortality in patients with RA-ILD. However, when stratified by two groups (high exposure (top 25th percentile) vs low exposure (bottom 75th percentile)), we observed a significant association between high PM10 exposure and mortality (HR 1.68; 95% CI 1.11 to 2.52; p=0.013) but no association between NO2 exposure and mortality. In the subgroup analyses, the effect of high PM10 exposure on mortality was significant in patients aged <65 years (HR 1.98; 95% CI 1.02 to 3.85; p=0.045). Conclusions Our results indicated that high PM10 exposure may be associated with mortality in patients with RA-ILD. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BMJ PUBLISHING GROUP | - |
dc.title | PM<sub>10</sub> increases mortality risk in rheumatoid arthritis-associated interstitial lung disease | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1136/rmdopen-2023-003680 | - |
dc.identifier.scopusid | 2-s2.0-85184734460 | - |
dc.identifier.wosid | 001161405700001 | - |
dc.identifier.bibliographicCitation | RMD OPEN, v.10, no.1 | - |
dc.citation.title | RMD OPEN | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | IDIOPATHIC PULMONARY-FIBROSIS | - |
dc.subject.keywordPlus | AIR-POLLUTION EXPOSURE | - |
dc.subject.keywordPlus | PARTICULATE MATTER | - |
dc.subject.keywordPlus | STANDARDIZATION | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordAuthor | Rheumatoid Arthritis | - |
dc.subject.keywordAuthor | Pulmonary Fibrosis | - |
dc.subject.keywordAuthor | Arthritis | - |
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