Top-down and bottom-up approaches for the estimation of measurement uncertainty in coagulation assays
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Yong Kwan | - |
dc.contributor.author | Kweon, Oh Joo | - |
dc.contributor.author | Lee, Mi-Kyung | - |
dc.contributor.author | Kim, Bohyun | - |
dc.contributor.author | Kim, Hye Ryoun | - |
dc.date.accessioned | 2021-08-11T08:34:06Z | - |
dc.date.available | 2021-08-11T08:34:06Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 1434-6621 | - |
dc.identifier.issn | 1437-4331 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2608 | - |
dc.description.abstract | Background: The assessment of measurement uncertainty (MU) in clinical laboratories is essential to the reliable interpretation of results in clinical laboratories. However, despite the introduction of various methods for the expression of uncertainty in measurement, the MUs of coagulation tests have not been extensively studied. The aim of this study was to quantify the MU of various coagulation assays according to international guidelines and to report an expected confidence in the quality of coagulation assays. Methods: We selected activated partial thromboplastin time, international normalized ratio (INR), protein C/S, antithrombin, fibrinogen, and Factor V/VIII/X to quantify the MUs of two coagulation testing systems: ACL TOP 750 CTS (Instrumentation Laboratory, Bedford, MA, USA) and STA Compact (Diagnostica Stago, Asnieres-sur-Seine, France). We used international standards and interlaboratory comparison results in accordance with international guidelines in a top-down approach to the assessment of MU. For INR, MU was estimated in a bottom-up approach using reference thromboplastin and certified plasmas. Results: Top-down approaches resulted in MUs between 3.3% and 21.3% for each measurand. In the bottom-up approach, MUs of INR values ranged from 10.9% to 26.4% and showed an upward trend as INR increased. Conclusions: In this study, we were successful in quantifying MU of coagulation assays using practical methods. Our results demonstrated that top-down and bottom-up approaches were adequate for coagulation assays. However, some assays showed significant biases against international standards; therefore, standardization would be necessary to ensure more reliable patient results. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Walter de Gruyter GmbH | - |
dc.title | Top-down and bottom-up approaches for the estimation of measurement uncertainty in coagulation assays | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1515/cclm-2020-0038 | - |
dc.identifier.scopusid | 2-s2.0-85083365940 | - |
dc.identifier.wosid | 000560715100027 | - |
dc.identifier.bibliographicCitation | Clinical Chemistry and Laboratory Medicine, v.58, no.9, pp 1525 - 1533 | - |
dc.citation.title | Clinical Chemistry and Laboratory Medicine | - |
dc.citation.volume | 58 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1525 | - |
dc.citation.endPage | 1533 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.subject.keywordPlus | INTERNATIONAL SENSITIVITY INDEX | - |
dc.subject.keywordPlus | PROTHROMBIN TIME | - |
dc.subject.keywordPlus | QUALITY-CONTROL | - |
dc.subject.keywordPlus | STANDARDIZATION | - |
dc.subject.keywordPlus | LABORATORIES | - |
dc.subject.keywordPlus | ANALYTES | - |
dc.subject.keywordAuthor | bias | - |
dc.subject.keywordAuthor | blood coagulation | - |
dc.subject.keywordAuthor | clinical laboratory tests | - |
dc.subject.keywordAuthor | laboratory proficiency testing | - |
dc.subject.keywordAuthor | measurement uncertainty | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.