Magnetic Resonance Imaging With Extracellular Contrast Detects Hepatocellular Carcinoma With Greater Accuracy Than With Gadoxetic Acid or Computed Tomography
DC Field | Value | Language |
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dc.contributor.author | Min, Ji Hye | - |
dc.contributor.author | Kim, Jong Man | - |
dc.contributor.author | Kim, Young Kon | - |
dc.contributor.author | Cha, Dong Ik | - |
dc.contributor.author | Kang, Tae Wook | - |
dc.contributor.author | Kim, Honsoul | - |
dc.contributor.author | Choi, Gyu Seong | - |
dc.contributor.author | Choi, Seo-Youn | - |
dc.contributor.author | Ahn, Soohyun | - |
dc.date.accessioned | 2021-08-11T08:34:08Z | - |
dc.date.available | 2021-08-11T08:34:08Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 1542-3565 | - |
dc.identifier.issn | 1542-7714 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2616 | - |
dc.description.abstract | BACKGROUND & AIMS: Computed tomography (CT) and magnetic resonance imaging (MRI) are used to detect hepatocellular carcinoma (HCC). We performed a prospective study to compare the diagnostic performance of CT, MRI with extracellular contrast agents (ECA-MRI), and MRI with hepatobiliary agents (HBA-MRI) in the detection of HCC using the liver imaging reporting and data system (LI-RADS). METHODS: We studied 125 participants (102 men; mean age, 55.3 years) with chronic liver disease who underwent CT, ECA-MRI, or HBA-MRI (with gadoxetic acid) before surgery for a nodule initially detected by ultrasound at a tertiary center in Korea, from November 2016 through February 2019. We collected data on major features and assigned LI-RADS categories (v2018) from CT and MRI examinations. We then compared the diagnostic performance for LR-5 for each modality alone, and in combination. RESULTS: In total, 163 observations (124 HCCs, 13 non-HCC malignancies, and 26 benign lesions; mean size, 20.7 mm) were identified. ECA-MRI detected HCC with 83.1% sensitivity and 86.6% accuracy, compared to 64.4% sensitivity and 71.8% accuracy for CT (P < .001) and 71.2% sensitivity (P = .005) and 76.5% accuracy for HBA-MRI (P = .005); all technologies detected HCC with 97.4% specificity. Adding CT to either ECA-MRI (89.2% sensitivity, 91.4% accuracy; both P < .05) or HBA-MRI (82.8% sensitivity, 86.5% accuracy; both P < .05) significantly increased its diagnostic performance in detection of HCC compared with the MRI technologies alone. ECA-MRI identified arterial phase hyperenhancement in a significantly higher proportion of patients (97.6%) than CT (81.5%; P < .001) or HBA-MRI (89.5%; P = .002). ECA-MRI identified non-peripheral washout in 79.8% of patients, vs 74.2% of patients for CT and 73.4% of patients for HBA-MRI (differences not significant). ECA-MRI identified enhancing capsules in 85.5% of patients, vs 33.9% for CT (P < .001) and 41.4% for HBA-MRI (P < .001). CONCLUSION: In a prospective study of patients with chronic liver disease and a nodule detected by ultrasound, ECA-MRI detected HCC with higher levels of sensitivity and accuracy than CT or HBA-MRI, based on LI-RADS. Diagnostic performance was best when CT was used in combination with MRI compared with MRI alone. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | W. B. Saunders Co., Ltd. | - |
dc.title | Magnetic Resonance Imaging With Extracellular Contrast Detects Hepatocellular Carcinoma With Greater Accuracy Than With Gadoxetic Acid or Computed Tomography | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.cgh.2019.12.010 | - |
dc.identifier.scopusid | 2-s2.0-85087931052 | - |
dc.identifier.wosid | 000550173100034 | - |
dc.identifier.bibliographicCitation | Clinical Gastroenterology and Hepatology, v.18, no.9, pp 2091 - + | - |
dc.citation.title | Clinical Gastroenterology and Hepatology | - |
dc.citation.volume | 18 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2091 | - |
dc.citation.endPage | + | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | GD-EOB-DTPA | - |
dc.subject.keywordPlus | HYPERVASCULAR HYPOINTENSE NODULES | - |
dc.subject.keywordPlus | CLINICAL-PRACTICE GUIDELINES | - |
dc.subject.keywordPlus | ENHANCED MRI | - |
dc.subject.keywordPlus | DIAGNOSTIC PERFORMANCE | - |
dc.subject.keywordPlus | HEPATOBILIARY AGENTS | - |
dc.subject.keywordPlus | CIRRHOTIC-PATIENTS | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | CT | - |
dc.subject.keywordPlus | PHASE | - |
dc.subject.keywordAuthor | Liver Cancer | - |
dc.subject.keywordAuthor | Early Detection | - |
dc.subject.keywordAuthor | Comparison | - |
dc.subject.keywordAuthor | Diagnosis | - |
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