Factors Associated With Achieving Complete Skin Clearance Compared to Almost Complete Skin Clearance in Patients With Moderate to Severe Psoriasis Treated With Biologics: A Retrospective Chart Review
DC Field | Value | Language |
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dc.contributor.author | Hong, Eun Ji | - |
dc.contributor.author | Yoon, Hee Jung | - |
dc.contributor.author | Kwon, Min Jung | - |
dc.contributor.author | Kim, Jae Yun | - |
dc.contributor.author | Kim, Jung Eun | - |
dc.contributor.author | Park, Young Lip | - |
dc.contributor.author | Lee, Sanghoon | - |
dc.contributor.author | Bae, Youin | - |
dc.contributor.author | Lee, Sul Hee | - |
dc.date.accessioned | 2024-06-11T08:30:27Z | - |
dc.date.available | 2024-06-11T08:30:27Z | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 1013-9087 | - |
dc.identifier.issn | 2005-3894 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26227 | - |
dc.description.abstract | Background: Biologics have demonstrated high efficacy in achieving 'almost complete' skin clearance in patients with moderate to severe psoriasis. Nonetheless, achieving 'complete' skin clearance remains a treatment goal for some highly biologics -resistant patients, as residual lesions impact their quality of life. Objective: The risk factors for failure to achieve a Psoriasis Area and Severity Index (PASI) 100 response in patients with good response to biologics remain unknown. Methods: This retrospective study evaluated the risk factors by comparing patients who achieved complete skin clearance (PASI100) with those who achieved almost complete skin clearance (PASI90). A database of 131 psoriasis patients treated with biologics, who achieved a PASI90 or PASI100 response, was reviewed from a tertiary referral hospital in South Korea. The patients were classified into PASI90 and PASI100 groups according to their PASI response. Results: The PASI100 group had a lower prevalence of smoking history (adjusted odds ratio [OR], 0.34; 95% confidence interval [CI], 0.14-0.85; p=0.021) and psoriasis on the anterior lower legs at baseline (adjusted OR, 0.18; 95% CI, 0.03-0.99; p=0.049) than patients in the PASI90 group. Conclusion: This study suggested that smoking history and psoriatic skin lesions on the anterior lower legs are considered as the risk factors for the failure to achieve a PASI100 response in psoriasis patients treated with biologics. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN DERMATOLOGICAL ASSOC | - |
dc.title | Factors Associated With Achieving Complete Skin Clearance Compared to Almost Complete Skin Clearance in Patients With Moderate to Severe Psoriasis Treated With Biologics: A Retrospective Chart Review | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5021/ad.23.074 | - |
dc.identifier.scopusid | 2-s2.0-85189516827 | - |
dc.identifier.wosid | 001196250900002 | - |
dc.identifier.bibliographicCitation | ANNALS OF DERMATOLOGY, v.36, no.2, pp 91 - 98 | - |
dc.citation.title | ANNALS OF DERMATOLOGY | - |
dc.citation.volume | 36 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 91 | - |
dc.citation.endPage | 98 | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART003068424 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | QUALITY-OF-LIFE | - |
dc.subject.keywordPlus | INDEX PASI | - |
dc.subject.keywordPlus | CLINICAL-RESPONSE | - |
dc.subject.keywordPlus | SYMPTOM SEVERITY | - |
dc.subject.keywordPlus | 2-PHASE 3 | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | AREA | - |
dc.subject.keywordPlus | IMPROVEMENTS | - |
dc.subject.keywordPlus | SECUKINUMAB | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordAuthor | Biologics | - |
dc.subject.keywordAuthor | Psoriasis | - |
dc.subject.keywordAuthor | Risk factors | - |
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