Brain network reconstruction of abnormal functional connectivity in Lennox-Gastaut syndrome according to drug responsiveness: A retrospective study
DC Field | Value | Language |
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dc.contributor.author | Park, Kang Min | - |
dc.contributor.author | Park, Soyoung | - |
dc.contributor.author | Hur, Yun Jung | - |
dc.date.accessioned | 2024-06-11T08:30:48Z | - |
dc.date.available | 2024-06-11T08:30:48Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 0920-1211 | - |
dc.identifier.issn | 1872-6844 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26266 | - |
dc.description.abstract | Objective: Functional network effects of resective or palliative epilepsy surgery in Lennox-Gastaut syndrome (LGS) patients are different according to the seizure outcome. This study aimed to clarify whether the response to antiseizure medications (ASM) can affect to alteration of brain network connectivity. Methods: In this retrospective study, 37 patients with LGS who underwent 1st electroencephalography (EEG) and 40 healthy controls were enrolled. Among them, 24 LGS patients had follow-up EEG data and were classified as drug responders and non-responders according to the ASM response. Graphical theoretical analysis was used to assess functional connectivity using resting-state EEG. Results: The 1st EEG showed a decreased radius in patients with LGS compared with that in healthy controls (3.987 vs. 4.279, P = 0.003). Follow-up EEG data of patients with LGS revealed significant differences in functional connectivity depending on the ASM response. On follow-up EEG, non-responders (n = 11) demonstrated significant increases in global network parameters, whereas responders (n = 13) showed no significant difference in functional connectivity compared with healthy controls. Conclusions: The functional connectivity patterns in patients with LGS differed from those in healthy controls. Functional connectivity in drug-responsive patients with LGS tended to preserve the network of brain connections in a pattern similar to that in healthy controls, whereas non-responders showed more disrupted functional connectivity. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER | - |
dc.title | Brain network reconstruction of abnormal functional connectivity in Lennox-Gastaut syndrome according to drug responsiveness: A retrospective study | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.eplepsyres.2024.107312 | - |
dc.identifier.scopusid | 2-s2.0-85184040723 | - |
dc.identifier.wosid | 001175374300001 | - |
dc.identifier.bibliographicCitation | EPILEPSY RESEARCH, v.200 | - |
dc.citation.title | EPILEPSY RESEARCH | - |
dc.citation.volume | 200 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | EPILEPSY | - |
dc.subject.keywordPlus | SPIKE | - |
dc.subject.keywordPlus | WAVE | - |
dc.subject.keywordAuthor | Lennox-Gastaut syndrome | - |
dc.subject.keywordAuthor | Antiseizure medication | - |
dc.subject.keywordAuthor | Functional connectivity | - |
dc.subject.keywordAuthor | Graphic theoretical analysis | - |
dc.subject.keywordAuthor | Electroencephalography | - |
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