Identification of patients with favorable prognosis after resection in intermediate-stage-hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | Lee, Han Ah | - |
dc.contributor.author | Lee, Minjong | - |
dc.contributor.author | Yoo, Jeong-Ju | - |
dc.contributor.author | Chun, Ho Soo | - |
dc.contributor.author | Park, Yewan | - |
dc.contributor.author | Kim, Hwi Young | - |
dc.contributor.author | Kim, Tae Hun | - |
dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Sinn, Dong Hyun | - |
dc.date.accessioned | 2024-06-12T02:30:16Z | - |
dc.date.available | 2024-06-12T02:30:16Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 1743-9191 | - |
dc.identifier.issn | 1743-9159 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26335 | - |
dc.description.abstract | Backgrounds: It is unclear which patients benefit from resection in intermediate-stage-hepatocellular carcinoma (HCC). The authors aimed to identify high-risk patients for early recurrence among patients with resectable intermediate-stage HCC. Methods: This multicenter retrospective study included patients who underwent resection or trans-arterial chemoembolization (TACE) for intermediate-stage HCC (2008-2019). Multivariable Cox proportional analysis was performed to identify high-risk patients when treated with resection. A prediction score for 2-year recurrence-free survival (RFS) was developed using the training cohort and validated. The 2-year RFS in each risk group was compared with that in TACE group, after propensity score matching (PSM). Results: A total of 1686 patients were included (480 and 1206 patients in the resection and TACE groups). During a median follow-up of 31.4 months, the 2-year RFS was significantly higher in the resection (47.7%) than in the TACE group (19.8%) [adjusted hazard ratio (aHR)=1.471, 95% CI: 1.199-1.803, P <0.001). On multivariate analysis, alpha-fetoprotein >= 5.0 ng/ml (aHR=0.202), ALBI grade >= 2 (aHR=0.709), tumor number >= 3 (aHR=0.404), and maximal tumor size >= 5 cm (aHR=0.323) were significantly associated with the lower risk of 2-year RFS in the resection group. The newly developed Surgery Risk score in BCLC-B (SR-B score) with four significant risk factors showed an area under the curve of 0.801 for the 2-year RFS and was validated. Based on the SR-B score, low-risk patients had a significantly higher 2-year RFS (training: aHR=5.834; validation: aHR=5.675) than high-risk patients (all P <0.001) did. In a PSM cohort, a low-risk resection group had a significantly higher (aHR=3.891); a high-risk resection group had a comparable 2-year RFS to those treated with TACE (aHR=0.816). Conclusions: Resection may be beneficial for resectable intermediate-stage HCC based on the SR-B score. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Identification of patients with favorable prognosis after resection in intermediate-stage-hepatocellular carcinoma | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1097/JS9.0000000000000941 | - |
dc.identifier.scopusid | 2-s2.0-85185218546 | - |
dc.identifier.wosid | 001164676800031 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF SURGERY, v.110, no.2, pp 1008 - 1018 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF SURGERY | - |
dc.citation.volume | 110 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 1008 | - |
dc.citation.endPage | 1018 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | TRANSARTERIAL CHEMOEMBOLIZATION | - |
dc.subject.keywordPlus | ARTERIAL CHEMOEMBOLIZATION | - |
dc.subject.keywordPlus | PARTIAL-HEPATECTOMY | - |
dc.subject.keywordPlus | HEPATIC RESECTION | - |
dc.subject.keywordPlus | SUBCLASSIFICATION | - |
dc.subject.keywordPlus | PROPOSAL | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | intermediate-stage | - |
dc.subject.keywordAuthor | resection | - |
dc.subject.keywordAuthor | trans-arterial chemoembolization | - |
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