Endobronchial valves for emphysema and persistent air-leak: 10-year experience in an Asian country
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Huh, Jin-Young | - |
dc.contributor.author | Jeong, Byeong-Ho | - |
dc.contributor.author | Yoon, Ho il | - |
dc.contributor.author | Kim, Hojoong | - |
dc.contributor.author | Cho, Young-Jae | - |
dc.contributor.author | Kim, Changhwan | - |
dc.contributor.author | Lee, Seung Jun | - |
dc.contributor.author | Kim, Hwan hee | - |
dc.contributor.author | Ra, Seung Won | - |
dc.contributor.author | Lee, Ye Jin | - |
dc.contributor.author | Kim, Beong Ki | - |
dc.contributor.author | Kim, Sung Kyoung | - |
dc.contributor.author | Seo, Ki Hyun | - |
dc.contributor.author | Lee, Sei Won | - |
dc.date.accessioned | 2024-06-12T02:30:29Z | - |
dc.date.available | 2024-06-12T02:30:29Z | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 1471-2466 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26355 | - |
dc.description.abstract | Background Endobronchial valve (EBV) therapy, a validated method for bronchoscopic lung volume reduction (BLVR) in severe emphysema, has been explored for persistent air-leak (PAL) management. However, its effectiveness and safety in the Asian population require further real-world evaluation. In this study, we assessed the outcomes of treatment with EBV within this demographic.Methods We conducted a retrospective analysis of medical records from 11 Korean centers. For the emphysema cohort, inclusion criteria were patients diagnosed with emphysema who underwent bronchoscopy intended for BLVR. We assessed these patients for clinical outcomes of chronic obstructive pulmonary disease. All patients with PAL who underwent treatment with EBV were included. We identified the underlying causes of PAL and evaluated clinical outcomes after the procedure.Results The severe emphysema cohort comprised 192 patients with an average age of 70.3 years, and 95.8% of them were men. Ultimately, 137 underwent treatment with EBV. Three months after the procedure, the BLVR group demonstrated a significant improvement in forced expiratory volume in 1 s (+160 mL vs. +30 mL; P = 0.009). Radiographic evidence of lung volume reduction 6 months after BLVR was significantly associated with improved survival (adjusted hazard ratio 0.020; 95% confidence interval 0.038-0.650; P = 0.010). Although pneumothorax was more common in the BLVR group (18.9% vs. 3.8%; P = 0.018), death was higher in the no-BLVR group (38.5% vs. 54.5%, P = 0.001), whereas other adverse events were comparable between the groups. Within the subset of 18 patients with PAL, the predominant causes of air-leak included spontaneous secondary pneumothorax (44.0%), parapneumonic effusion/empyema (22.2%), and post-lung resection surgery (16.7%). Following the treatment, the majority (77.8%) successfully had their chest tubes removed. Post-procedural complications were minimal, with two incidences of hemoptysis and one of empyema, all of which were effectively managed.Conclusions Treatment with EBV provides substantial clinical benefits in the management of emphysema and PAL in the Asian population, suggesting a favorable outcome for this therapeutic approach. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BMC | - |
dc.title | Endobronchial valves for emphysema and persistent air-leak: 10-year experience in an Asian country | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1186/s12890-024-02982-2 | - |
dc.identifier.scopusid | 2-s2.0-85189339012 | - |
dc.identifier.wosid | 001197244300001 | - |
dc.identifier.bibliographicCitation | BMC PULMONARY MEDICINE, v.24, no.1 | - |
dc.citation.title | BMC PULMONARY MEDICINE | - |
dc.citation.volume | 24 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | LUNG-VOLUME REDUCTION | - |
dc.subject.keywordPlus | RACIAL-DIFFERENCES | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | PREDICTORS | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Chronic obstructive pulmonary disease | - |
dc.subject.keywordAuthor | Emphysema | - |
dc.subject.keywordAuthor | Pneumothorax | - |
dc.subject.keywordAuthor | Bronchoscopies | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.