NK cell-activating receptor NKp46 does not participate in the development of obesity-induced inflammation and insulin resistance
DC Field | Value | Language |
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dc.contributor.author | Nathalie, Gracia | - |
dc.contributor.author | Bonamichi, Beatriz Dal Santo Francisco | - |
dc.contributor.author | Kim, Jieun | - |
dc.contributor.author | Jeong, Jiwon | - |
dc.contributor.author | Kang, Haneul | - |
dc.contributor.author | Hartland, Emirrio Reinaldie | - |
dc.contributor.author | Eveline, Eveline | - |
dc.contributor.author | Lee, Jongsoon | - |
dc.date.accessioned | 2024-06-12T02:30:33Z | - |
dc.date.available | 2024-06-12T02:30:33Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.issn | 0219-1032 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26365 | - |
dc.description.abstract | Recent evidence establishes a pivotal role for obesity -induced inflammation in precipitating insulin resistance and type -2 diabetes. Central to this process is the proinflammatory M1 adipose -tissue macrophages (ATMs) in epididymal white adipose tissue (eWAT). Notably, natural killer (NK) cells are a crucial regulator of ATMs since their cytokines induce ATM recruitment and M1 polarization. The importance of NK cells is shown by the strong increase in NK-cell numbers in eWAT, and by studies showing that removing and expanding NK cells respectively improve and worsen obesity -induced insulin resistance. It has been suggested that NK cells are activated by unknown ligands on obesity -stressed adipocytes that bind to NKp46 (encoded by Ncr1 ), which is an activating NK-cell receptor. This was supported by a study showing that NKp46knockout mice have improved obesity -induced inflammation/insulin resistance. We therefore planned to use the NKp46knockout mice to further elucidate the molecular mechanism by which NKp46 mediates eWAT NK-cell activation in obesity. We confirmed that obesity increased eWAT NKp46 + NK-cell numbers and NKp46 expression in wild -type mice and that NKp46-knockout ablated these responses. Unexpectedly, however, NKp46-knockout mice demonstrated insulin resistance similar to wild -type mice, as shown by fasting blood glucose/insulin levels and glucose/insulin tolerance tests. Obesityinduced increases in eWAT ATM numbers and proinflammatory gene expression were also similar. Thus, contrary to previously published results, NKp46 does not regulate obesity -induced insulin resistance. It is therefore unclear whether NKp46 participates in the development of obesity -induced inflammation and insulin resistance. This should be considered when elucidating the obesity -mediated molecular mechanisms that activate NK cells. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | NK cell-activating receptor NKp46 does not participate in the development of obesity-induced inflammation and insulin resistance | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1016/j.mocell.2023.100007 | - |
dc.identifier.scopusid | 2-s2.0-85185936083 | - |
dc.identifier.wosid | 001220763900001 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.47, no.3 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 47 | - |
dc.citation.number | 3 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | INNATE LYMPHOID-CELLS | - |
dc.subject.keywordPlus | ACCUMULATION | - |
dc.subject.keywordPlus | ABLATION | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Insulin resistance | - |
dc.subject.keywordAuthor | Natural killer cells | - |
dc.subject.keywordAuthor | Obesity | - |
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