Feasibility of intraoperative pathologic examination for sentinel lymph nodes during sentinel node navigation surgery in early gastric cancer: results of pathologic protocol for SENORITA trial
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sin Hye | - |
dc.contributor.author | Chung, Soo Young | - |
dc.contributor.author | Lee, Jeong-Hee | - |
dc.contributor.author | Kim, Hee Kyung | - |
dc.contributor.author | Lee, Dakeun | - |
dc.contributor.author | Kim, Hyunki | - |
dc.contributor.author | Kim, Jo-Heon | - |
dc.contributor.author | Kim, Min Seok | - |
dc.contributor.author | Lee, Jae Hyuk | - |
dc.contributor.author | Park, Ji Yeon | - |
dc.contributor.author | Yoon, Hong Man | - |
dc.contributor.author | Ryu, Keun Won | - |
dc.contributor.author | Kook, Myeong-Cherl | - |
dc.date.accessioned | 2024-06-12T02:30:39Z | - |
dc.date.available | 2024-06-12T02:30:39Z | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 1436-3291 | - |
dc.identifier.issn | 1436-3305 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26376 | - |
dc.description.abstract | BackgroundDuring sentinel node navigation surgery in patients with gastric cancer, intraoperative pathologic examination of sentinel nodes is crucial in determining the extent of surgery. In this study, we evaluated the feasibility and accuracy of intraoperative pathologic protocols using data from a prospective, multicenter, randomized trial.MethodsA retrospective analysis was conducted using data from the SEntinel Node ORIented Tailored Approach trials from 2013 to 2016. All sentinel lymph nodes were evaluated during surgery with hematoxylin-eosin (HE) staining using a representative section at the largest plane for lymph nodes. For permanent histologic evaluation, sentinel basin nodes were stained with HE and cytokeratin immunohistochemistry in formalin-fixed, paraffin-embedded (FFPE) sections and examined with HE for three deeper-step sections at 200-mu m intervals. The failure rate of identification by frozen section and the metastasis rate in non-sentinel basins were investigated.ResultsOf the 237 patients who underwent sentinel node basin dissection, 30 had lymph node metastases on permanent pathology. Thirteen patients had macrometastasis confirmed in frozen sections as well as FFPE sections (failure rate: 0%). Patients with negative sentinel nodes in frozen sections but micrometastasis in FFPE sections had no lymph node recurrence during the follow-up period (0%, 0/6). However, in cases with tumor-positive nodes in frozen sections, metastases in non-sentinel basins were detected in the paraffin blocks (8.3%, 2/24).ConclusionsThe single-section HE staining method is sufficient for detecting macrometastasis via intraoperative pathological examination. If a negative frozen-section result is confirmed, sentinel basin dissection can be performed safely. Otherwise, standard surgery is required. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | Feasibility of intraoperative pathologic examination for sentinel lymph nodes during sentinel node navigation surgery in early gastric cancer: results of pathologic protocol for SENORITA trial | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s10120-024-01497-3 | - |
dc.identifier.scopusid | 2-s2.0-85191063933 | - |
dc.identifier.wosid | 001206035900001 | - |
dc.identifier.bibliographicCitation | GASTRIC CANCER | - |
dc.citation.title | GASTRIC CANCER | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | MULTICENTER TRIAL | - |
dc.subject.keywordPlus | BIOPSY | - |
dc.subject.keywordPlus | MICROMETASTASES | - |
dc.subject.keywordPlus | DISSECTION | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | RESECTION | - |
dc.subject.keywordAuthor | Stomach neoplasm | - |
dc.subject.keywordAuthor | Sentinel lymph node | - |
dc.subject.keywordAuthor | Frozen section | - |
dc.subject.keywordAuthor | Lymph node metastasis | - |
dc.subject.keywordAuthor | Early gastric cancer | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.