Efficacy, tolerability, and safety of oral sulfate tablet versus 2 L-polyethylene glycol/ascorbate for bowel preparation in older patients: prospective, multicenter, investigator single-blinded, randomized study
DC Field | Value | Language |
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dc.contributor.author | Kang, Ho Suk | - |
dc.contributor.author | Na, Soo-Young | - |
dc.contributor.author | Yoon, Jin Young | - |
dc.contributor.author | Jung, Yunho | - |
dc.contributor.author | Seo, Geom Seog | - |
dc.contributor.author | Cha, Jae Myung | - |
dc.date.accessioned | 2024-06-12T02:30:46Z | - |
dc.date.available | 2024-06-12T02:30:46Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 0944-1174 | - |
dc.identifier.issn | 1435-5922 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26397 | - |
dc.description.abstract | Background: We compared the efficacy, tolerability, and safety of oral sulfate tablets (OST, which contains simethicone) and 2 L-polyethylene glycol/ascorbate (2 L-PEG/Asc) with a split-dosing regimen in older individuals aged >= 70 years who underwent scheduled colonoscopy. Methods: This prospective, randomized, investigator-blinded, multicenter study was conducted between June 2022 and October 2023. Participants aged >= 70 years were randomized at a ratio of 1:1 to the OST or 2 L-PEG/Asc groups. Results: In total, 254 patients were evaluated using a modified full analysis set. Successful overall bowel preparation was excellent and similar between the OST and 2 L-PEG/Asc groups for the Boston Bowel Preparation Scale (BBPS) (96.5% vs. 96.6%) and Harefield Cleansing Scale (HCS) (96.5% vs. 97.4%). The overall high-quality preparation rate was higher in the OST group than in the 2 L-PEG/Asc group (BBPS: 55.7% vs. 28.4%, P < 0.001; HCS: 66.1% vs. 38.8%, P < 0.001). The overall adenoma detection rate (54.8% vs. 35.3, P = 0.003) was superior in the OST group compared to the 2 L-PEG/Asc group. Tolerability scores, including overall satisfaction, were generally higher in the OST group than in the 2 L-PEG/Asc group. The incidence of major solicited adverse events was comparable between the two groups (55.7% vs. 68.1, P = 0.051), and there were no clinically significant changes in the serum laboratory profiles on the day of or 7 days after colonoscopy. Conclusions: OST is an effective and safe low-volume agent for colonoscopy, with better tolerance than 2 L-PEG/Asc, in older individuals aged >= 70 years. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER JAPAN KK | - |
dc.title | Efficacy, tolerability, and safety of oral sulfate tablet versus 2 L-polyethylene glycol/ascorbate for bowel preparation in older patients: prospective, multicenter, investigator single-blinded, randomized study | - |
dc.type | Article | - |
dc.publisher.location | 일본 | - |
dc.identifier.doi | 10.1007/s00535-024-02089-9 | - |
dc.identifier.scopusid | 2-s2.0-85187931114 | - |
dc.identifier.wosid | 001185911700001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY, v.59, no.5, pp 402 - 410 | - |
dc.citation.title | JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.volume | 59 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 402 | - |
dc.citation.endPage | 410 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | QUALITY | - |
dc.subject.keywordPlus | COLONOSCOPY | - |
dc.subject.keywordPlus | SCALE | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordAuthor | Aged | - |
dc.subject.keywordAuthor | Cathartics | - |
dc.subject.keywordAuthor | Colonoscopy | - |
dc.subject.keywordAuthor | Efficacy | - |
dc.subject.keywordAuthor | Safety | - |
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