Cefepime-Induced Encephalopathy in a Tertiary Medical Center in Korea
- Authors
- Jeon, Ji-Ye; Cho, Yong Won; Moon, Hye-Jin
- Issue Date
- Jul-2020
- Publisher
- 대한신경과학회
- Keywords
- encephalopathy; cefepime; epilepsy; incidence; electroencephalography
- Citation
- Journal of Clinical Neurology, v.16, no.3, pp 408 - 415
- Pages
- 8
- Journal Title
- Journal of Clinical Neurology
- Volume
- 16
- Number
- 3
- Start Page
- 408
- End Page
- 415
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2672
- DOI
- 10.3988/jcn.2020.16.3.408
- ISSN
- 1738-6586
2005-5013
- Abstract
- Background and Purpose Cefepime is a widely used fourth-generation cephalosporin. It is commonly used as a first-line antibiotic to treat various infectious diseases such as hospital-acquired pneumonia, urinary tract infections, and bacterial meningitis. The primary outcome of this study was the development of cefepime-induced encephalopathy (CIE) at a tertiary medical center in Korea. We also aimed to describe the clinical features of CIE. Methods We enrolled 1,793 consecutive patients treated with cefepime. The CIE group included 44 patients who experienced altered consciousness after receiving cefepime without any other obvious cause and showed full recovery after stopping cefepime. This study collected demographic data, laboratory findings, and clinical data including the cause of infection, duration for onset of altered consciousness, duration of cefepime treatment, dosage of cefepime, duration of recovering consciousness after stopping cefepime, sequelae after encephalopathy, and electroencephalography data. Results Forty-four (2.5%) patients were included in the CIE group. The age was significantly higher in the CIE group than in the control group (71.2 +/- 10.8 years vs. 64.7 +/- 16.1 years, mean +/- standard deviation; p=0.007), and females constituted a significantly large proportion in the CIE group (27 of 44, 61.4%). The CIE group had higher blood urea nitrogen (34.7 +/- 22.6 mg/dL vs. 23.0 +/- 17.5 mg/dL, p<0.001) and creatinine (2.2 +/- 2.5 mg/dL vs. 1.1 +/- 1.3 mg/dL, p<0.001), and lower estimated glomerular filtration rate (eGFR) (56.3 +/- 46.0 mL/min/1.73 mm(2) vs. 98.8 +/- 66.3 mL/min/1.73 mm(2), p<0.001). Multivariate analysis showed that only eGFR was significantly related to CIE. Conclusions The incidence of CIE was 2.5% in this study. It is essential to consider the possibility of CIE occurring, especially in patients with lower values of eGFR and dialysis.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Neurology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2672)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.