Protocatechuic Aldehyde Attenuates UVA-induced Photoaging in Human Dermal Fibroblast Cells by Suppressing MAPKs/AP-1 and NF-kappa B Signaling Pathways
DC Field | Value | Language |
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dc.contributor.author | Ding, Yuling | - |
dc.contributor.author | Jiratchayamaethasakul, Chanipa | - |
dc.contributor.author | Lee, Seung-Hong | - |
dc.date.accessioned | 2021-08-11T08:34:21Z | - |
dc.date.available | 2021-08-11T08:34:21Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2679 | - |
dc.description.abstract | Ultraviolet radiation (UV) is a major causative factor of DNA damage, inflammatory responses, reactive oxygen species (ROS) generation and a turnover of various cutaneous lesions resulting in skin photoaging. The purpose of this study is to investigate the protective effect of protocatechuic aldehyde (PA), which is a nature-derived compound, against UVA-induced photoaging by using human dermal fibroblast (HDF) cells. In this study, our results indicated that PA significantly reduced the levels of intracellular ROS, nitric oxide (NO), and prostaglandins-E-2(PGE(2)) in UVA-irradiated HDF cells. It also inhibited the levels of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression. Besides, PA significantly suppressed the expression of matrix metalloproteinases-1 (MMP-1) and pro-inflammatory cytokines and promoted collagen synthesis in the UVA-irradiated HDF cells. These events occurred through the regulation of activator protein 1 (AP-1), nuclear factor-kappa B (NF-kappa B), and p38 signaling pathways in UVA-irradiated HDF cells. Our findings suggest that PA enhances the protective effect of UVA-irradiated photoaging, which is associated with ROS scavenging, anti-wrinkle, and anti-inflammatory activities. Therefore, PA can be a potential candidate for the provision of a protective effect against UVA-stimulated photoaging in the pharmaceutical and cosmeceutical industries. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Protocatechuic Aldehyde Attenuates UVA-induced Photoaging in Human Dermal Fibroblast Cells by Suppressing MAPKs/AP-1 and NF-kappa B Signaling Pathways | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/ijms21134619 | - |
dc.identifier.scopusid | 2-s2.0-85087113783 | - |
dc.identifier.wosid | 000550272400001 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.21, no.13 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 21 | - |
dc.citation.number | 13 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | P38 MAPK | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | METALLOPROTEINASES | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordAuthor | ultraviolet A | - |
dc.subject.keywordAuthor | protocatechuic aldehyde | - |
dc.subject.keywordAuthor | photoaging | - |
dc.subject.keywordAuthor | matrix metalloproteinases-1 | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordAuthor | human dermal fibroblast cells | - |
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